EMR1 is predominantly expressed on the surface of macrophages and plays a significant role in immune response modulation and inflammation. Its expression has been linked to various inflammatory diseases.

2007年9月26日 · Applying flow cytometric analysis using the newly generated mAb A10, and quantitative real-time PCR, we here report the surprising observation that the human ortholog of F4/80, EGF-like module containing mucin-like hormone receptor (EMR)1, is absent on mononuclear phagocytic cells including monocytes, macrophages, and myeloid dendritic cells.

Applying flow cytometric analysis using the newly generated mAb A10, and quantitative real-time PCR, we here report the surprising observation that the human ortholog of F4/80, EGF-like module containing mucin-like hormone receptor (EMR)1, is absent on mononuclear phagocytic cells including monocytes, macrophages, and myeloid dendritic cells.

To explore the potential of the human eosinophil surface receptor, EGF-like module containing mucin-like hormone receptor 1 (EMR1), as a therapeutic target for eosinophilic disorders.

2007年11月6日 · like module containing mucin-like hormone receptor (EMR)1, is absent on mono-nuclear phagocytic cells including monocytes, macrophages, and myeloid dendritic cells. Unexpectedly, we found that EMR1 expression is restricted to eosinophilic granulocytes, where expression is overlapping with the eotaxin receptor CCR3 and the

CD311 (EMR1) is a member of the epidermal growth factor seven transmembrane spanning protein family [56]. It is found on monocytes and DC. It is the human homologue of the F4/80 antigen, which is the most widely used marker for mouse macrophages.

2022年3月24日 · f4/80 是一种 160 kd 细胞表面糖蛋白，它是 egf-tm7 蛋白家族的成员，与含有人 egf 模块的粘蛋白样激素受体 1 (emr1) 具有 68% 的整体氨基酸同一性。 F4/80是一个七次跨膜蛋白，胞外侧包含多个EGF序列。

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Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 27044-1-AP (EMR1 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).