细胞外基质对 EMT 的作用 | Cell Signaling Technology
这种降解的一个主要驱动因素是基质金属蛋白酶 (MMP) 进行蛋白水解消化，其中，MMP 的表达由 EMT 相关的信号转导通路（例如 TGF-β）进行调节。 促 EMT 转录因子（例如 SNAIL）对编码 …
Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition ...
The relationships which exist between the EMT and MMP-2-activation, especially those which are common to different systems, may provide insights into the implication of MMPs in EMT …
上皮间质转化(EMT)4种标志物介绍 - 知乎 - 知乎专栏
emt和met参与了 干细胞表型 变化和细胞迁移的调控，是细胞差异分化和三维组织构建的重要机制。 上皮间质转化过程 激活上皮间质转化（EMT）是癌细胞转移的关键过程，在此过程中，上 …
国自然划重点：红透半边天的EMT机制研究及相关通路 - 知乎
AIBP 通过HIF1-a介导的EMT抑制肝细胞癌侵袭转移的研究; ING4/miR-940/Snail1途径 调控结直肠癌EMT和转移的作用及机制; MTDH 通过Wnt/β-catenin和Wnt/PCP通路协同介导舌癌细 …
基质金属蛋白酶（MMPs）种类及功能 - 知乎 - 知乎专栏
基质金属蛋白酶（MMPs），1962年首先被确定为一种胶原蛋白水解酶，在蝌蚪尾巴的吸收过程中导致ECM蛋白降解。 属于metzincins超家族，是一类锌依赖性内肽酶，可降解ECM的各种蛋 …
The Role of Matrix Metalloproteinases in the …
2019年11月26日 · MMP-7 was found to function as a prometastatic factor by promoting the migratory and invasive ability of cancer cells, and overexpression of MMP-7 was found in HCC …
MMPs as potential molecular targets in epithelial-to-mesenchymal ...
2024年9月1日 · Epithelial-mesenchymal transition (EMT) is a significant process in airway remodeling during COPD and lung cancer. Pharmacological inhibition of MMPs is potential …
Matrix metalloproteinases: Master regulators of tissue …
2025年1月15日 · Matrix metalloproteinases (MMPs) control the complex processes of morphogenesis and tissue remodelling. They are important for both homeostatic and …
MMP-2 plays an essential role in producing epithelial …
MMP-2 is expressed as neural crest cells detach from the neural epithelium during an epithelial-mesenchymal transformation (EMT) but is rapidly extinguished as they disperse. It is also …
Role of MMP-9 in epithelial-mesenchymal transition of thyroid …
2020年7月22日 · Expression levels of EMT-related markers: epithelial cell marker E-cadherin and stromal cell marker Vimentin in TGF-1-induced TC cell lines were detected by Western blot …