The molecular pathogenesis of the type 2 inflammatory disease eosinophilic esophagitis (EoE) is largely driven by IL-13-mediated effects. A humanized monoclonal anti-IL-13 antibody …

RPC4046, a recombinant humanized monoclonal antibody against IL13, prevents its binding to the receptor subunits IL13RA1 and IL13RA2. We performed a phase 2 trial to evaluate the …

Eosinophilic esophagitis (EoE) is associated with allergen-driven inflammation of the esophagus and an upregulated Th2 cytokine signature. Recombinant interleukin (IL)-13 (rIL-13) …

2018年7月19日 · Eosinophilic esophagitis (EoE) is a chronic, esophageal, type 2 inflammatory response associated with increased serum levels of interleukin 13 (IL13), which might …

2016年8月1日 · Recent studies have highlighted a major contribution for IL-13 in EoE pathogenesis. Paired immunoglobulin-like receptor (PIR)-B is a cell surface immune-inhibitory …

Conclusions: Taken together, we propose that the pathogenesis of EE is mediated by an IL-13-stimulated keratinocyte-derived transcriptome that is largely reversible with corticosteroid …

2016年8月1日 · In this study, we demonstrate a key inhibitory function for PIR-B in EoE pathogenesis; overexpression of IL-13 in Pirb−/− mice leads to exaggerated EoE, including …

2017年10月10日 · Our findings — that actin-associated proteins are significantly upregulated in EoE, correlate with EoE severity, and alter esophageal epithelial integrity in cultured cells — …

2023年12月1日 · Clinical and experimental studies provide corroborative evidence of a central role for IL-13 in the esophageal allergic inflammatory response and histopathologic features of …

2021年3月1日 · Interleukin 13 (IL13), a pleotropic cytokine involved in T-helper cell 2–type inflammation, plays an important role in the pathogenesis of EoE. 21 IL13 is overexpressed in …