The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16.

2024年12月25日 · EP300 (E1A Binding Protein P300) is a Protein Coding gene. Diseases associated with EP300 include Rubinstein-Taybi Syndrome 2 and Menke-Hennekam Syndrome 2. Among its related pathways are Nuclear events mediated by NFE2L2 and RNA Polymerase I Promoter Opening.

EP300 ( 腺病毒E1A 结合蛋白,又称为P300 或者KAT3B)是组蛋白乙酰转移酶家族中的一员,其通过调控靶基因的表达,参与调整细胞生长、分裂、增殖、成熟和分化、细胞周期、凋亡等,与人类多种疾病的发病机制有关。 越来越多的研究表明,EP300的表达改变或突变与癌症的发生发展密切相关[4],并且存在双重作用,即不同的癌症类型或者在癌症的不同阶段表现为抑癌或者促癌作用,其对癌症影响的结果也大相径庭,但具体作用机制是多样化的,目前研究较为零散。 本文就EP300对癌症 …

EP300 (腺病毒E1A结合蛋白，又称为P300或者KAT3B)是组蛋白乙酰转移酶家族中的一员，其通过调控靶基因的表达，参与调整细胞生长、分裂、增殖、成熟和分化、细胞周期、凋亡等，与人类多种疾病的发病机制有关。 越来越多的研究表明，EP300的表达改变或突变与癌症的发生发展密切相关 [4] ，并且存在双重作用，即不同的癌症类型或者在癌症的不同阶段表现为抑癌或者促癌作用，其对癌症影响的结果也大相径庭，但具体作用机制是多样化的，目前研究较为零散。 本文 …

It functions as Histone Acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.

CREB-binding protein (CREBBP) and E1A-binding protein P300 (EP300) are two key acetyltransferases and transcriptional cofactors that regulate gene expression by regulating the acetylation levels of histone proteins and non-histone proteins.

The EP300 gene provides instructions for making a protein called p300, which regulates the activity of many genes in tissues throughout the body. This protein plays an essential role in controlling cell growth and division and prompting cells to mature and take on specialized functions (differentiate).

2025年2月9日 · Knockdown of E1A binding protein p300 (EP300) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1: PubMed

Gene ID: 2033, updated on 9-Feb-2025. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation.

2022年3月1日 · ep300是一种在增殖和分化中重要的转录共激活因子，在包括小细胞肺癌在内的多种癌症类型中经常发生突变。虽然这些突变被认为会导致ep300功能丧失，但对肿瘤发生的影响仍不清楚。