EP4 4 receptors are expressed in the cochlea of the inner ear. Pre- and post-treatment of guinea pigs with an EP4 agonist significantly attenuated threshold shifts of auditory brain stem responses and significantly reduced the loss of outer hair cells caused by prior noise exposure.

In this review, we summarize the physiological roles of EP4, its molecular structure and intracellular signaling pathways, and how EP4 receptors might be targeted pharmacologically for the benefit of human disease, including vascular and …

In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been proposed for the EP4 receptor, along with its recently described unfavorable tumor-promoting and pro-angiogenic roles.

2024年11月1日 · In this study, we investigate the gene expression signature associated with EP4 and EP2 expression in immune cells infiltrating human cancers using single-cell RNA sequencing (scRNAseq).

An EP4 receptor is a type of cell surface receptor that, upon binding with PGE2, regulates cell signaling pathways, including cAMP/PKA-dependent pathways as well as other pathways like PI3K/AKT/mTOR and MAPK pathways.

2013年6月17日 · The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It belongs to the family of G protein-coupled receptors. It was originally identified, similar to the EP2 receptor as a G(s)α-coupled, adenylyl cyclase-stimulating receptor.

2018年12月3日 · Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal structure of human EP4 in complex with...

The EP4 (prostaglandin E2) receptor plays a crucial role in myogenesis and skeletal muscle regeneration, yet its involvement in regulating insulin-dependent metabolic pathways is not well characterised.

2022年3月8日 · We developed a novel EP4 antagonist HL-43 that can promote cartilage repair, enhance stable mature articular cartilage formation instead of fibrocartilage formation, delay chondrocyte terminal...

Prostaglandin E2 (PGE2) receptor 4 (EP4) is one of four EP receptors commonly upregulated in the tumor microenvironment and plays vital roles in stimulating cell proliferation, invasion, and metastasis. Biochemical blockade of the PGE2–EP4 signaling ...