Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. Filtered by similarity ? Compute overlaps ? Compendia expression …

2023年9月15日 · ER stress activates an adaptive unfolded protein response to restore proteostasis by initiating protein kinase R-like ER kinase, activating transcription factor 6, and …

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. [1] It has been found to be conserved between mammalian species, [2] …

2012年1月18日 · ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates the recovery of ER function, and failure to …

2020年5月26日 · To ensure protein folding fidelity and to maintain ER functions, the unfolded protein response (UPR) of eukaryotic cells evolved to a network of signal transduction …

ER stress activates a signaling network called the Unfolded Protein Response (UPR) to alleviate this stress and restore ER homeostasis, promoting cell survival and adaptation. However, …

As the name suggests, the UPR ER is most well described as a functional response to protein misfolding stress. Here, we focus on recent findings and emerging themes in additional roles …

The unfolded protein response (UPR) is the cells’ way of maintaining the balance of protein folding in the endoplasmic reticulum, which is the section of the cell designated for folding …

2017年6月15日 · In multicellular eukaryotes, the UPR ER consists of three distinct arms defined by ER transmembrane sensors: inositol-requiring protein 1 (IRE1), activating transcription …

Here, we describe two sets of methods for monitoring the occurrence of ER stress and UPR signaling in human cells by analyzing markers of activation of all three ER stress sensor …