2024年10月18日 · Here we show that ESCC can be categorized into differentiated, metabolic, immunogenic and stemness subtypes based on bulk and single-cell RNA-seq, each exhibiting specific molecular and...

2014年8月24日 · Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers 1. We performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent...

2025年1月1日 · In this study involving 12 metastatic ESCC patients, we employed single-cell sequencing, spatial transcriptomics (ST), and multiplex immunohistochemistry (mIHC) to explore the spatial and...

2024年10月18日 · Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies. To address this, we perform genomic-transcriptomic characterizations and AI-aided his …

2023年6月1日 · Our study aims to investigate the cellular origin of EVs in ESCC, and unveil the unknown molecular and cellular mechanisms underlying cell-cell communications. Six ESCC patients were enrolled and single-cell RNA sequencing (scRNA-seq) analyses were conducted to screen different cell subpopulations.

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has …

2021年5月10日 · The identification and characterization of gene mutation and expression heterogeneity across different ESCC datasets, including various novel TP53 mutations, ECM-receptor interaction, Focal adhesion, and Olfactory transduction pathways (CNGB1), provide researchers with evidence and implications for accurate research and precision therapeutic ...

2014年8月26日 · 生物通报道 来自中国医学科学院的研究人员采用外显子组测序，绘制出了食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）的遗传图谱。 研究结果发表在8月24日的《自然遗传学》（Nature Genetics）杂志上。 领导这一研究的是中国医学科学院肿瘤医院肿瘤研究所的赫捷（Jie He）教授。 其长期从事肺癌、食管癌等胸部肿瘤疾病的早诊早治、外科治疗及综合治疗，并在食管癌、肺癌综合治疗大型研究中取得较大成果。 于2013年当选为中国 …

食管鳞状上皮癌前病变（Esophageal squamous precancerous lesions, ESPL）是ESCC的前体病变，表现出从正常上皮（NE）到低级别（LGIN）和高级别（HGIN） 上皮内瘤变 的进展，最终发展为浸润性癌。一份长达13.5年的随访数据表明，较高级别的上皮内瘤变与ESCC发生的风险明显 ...

2022年9月7日 · Esophageal squamous cell cancer (ESCC) is the major pathologic type of esophageal cancer in Asian population. To systematically evaluate the mutational...