2024年10月18日 · Here we show that ESCC can be categorized into differentiated, metabolic, immunogenic and stemness subtypes based on bulk and single-cell RNA-seq, each exhibiting specific molecular and...

Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are the two main EC histological subtypes that have distinct epidemiological and clinical features. Globally, ESCC is the most common EC subtype, which accounts for 80% of EC cases, and it can anatomically develop throughout the esophagus .

2023年3月25日 · Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving...

2021年5月1日 · Most of the esophageal cancer (EC) is esophageal squamous cell carcinoma (ESCC) or esophageal adenocarcinoma (EAC), which is a malignant tumor originating from the esophageal epithelium. Global epidemiological data in 2020 showed that EC ranks seventh in terms of incidence (604,100 new cases) and sixth in the overall mortality (544,076 deaths ...

2021年7月22日 · The role of cis -elements and their aberrations remains unclear in esophageal squamous cell carcinoma (ESCC, further abbreviated EC). Here we survey 28 H3K27ac-marked active enhancer profiles...

2021年5月1日 · More than 600,000 people are diagnosed with esophageal cancer (EC) every year globally, and the five-year survival rate of EC is less than 20%. Two common histological subtypes of EC, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), have great geographical variations in …

2021年11月1日 · Esophageal cancer (EC) is one of the most common cancers with high morbidity and mortality rates. EC includes two histological subtypes, namely esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). ESCC primarily occurs in East Asia, whereas EAC occurs in Western countries.

2024年10月15日 · The complex molecular mechanisms underlying EC, coupled with the differential incidence of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) across various regions, highlight the necessity for in-depth research targeting molecular pathogenesis and innovative treatment strategies.

2023年4月17日 · 通过蛋白质基因组学阐明了ESCC进展中的癌症驱动波，并揭示了饮酒习惯相关特征的分子特性，确定了ESCC致癌过程中的6条主要轨迹及其分子特征。 文章发表在 Nature Communications. 研究团队从154名既往未经历过化疗或放疗的ESCC患者中，收集了786份微量样本进行了基于多组学的分析，涵盖9个组织病理学阶段和22个亚阶段（图1）；从49例早期ESCC患者中收集了另外256个样本作为独立验证队列。 研究团队对所有786个样本进行质谱（MS）分 …

2023年7月16日 · 食道癌（EC）是一种严重威胁人类健康的消化系统恶性肿瘤，分为食管腺癌（EAC）和食管鳞状细胞癌（ESCC）两种组织学亚型。 中国ESCC的发病率较高，约占总EC病例的90%。 ESCC早期症状并不明显，多数患者确诊时已是中晚期，其预后较差、5年生存率较低。 目前，内镜筛查和早期干预是降低ESCC发病率和死亡率的有效方法。 但目前内窥镜筛查多在中国的高风险地区进行。 因此，亟需开发可靠的生物标志物以应用于ESCC的早期检测和筛查。 …