
Endothelial Cell-Specific Molecule 1 Promotes Endothelial to ...
2020年8月6日 · The endothelial-to-mesenchymal transition (EndoMT) is involved in the complex pathogenesis of renal fibrosis. The soluble proteoglycan endothelial cell-specific molecule 1 (ESM1) is significantly upregulated in many tumor cells and cirrhosis-related disease. The role of ESM1 in renal fibrosis is unk …
Endothelial-secreted Endocan activates PDGFRA and regulates
2025年1月7日 · Subsequent RNA-sequencing (RNA-seq) revealed ESM1 as the most significantly upregulated gene in tumor-derived CD31 + cells compared to the non-neoplastic counterparts (Fig. 1c). In the TCGA...
Single-cell atlas of the human brain vasculature across …
2024年7月10日 · CD31 + CD45 − ECs showed consistent expression of classical endothelial markers, such as CD31, VWF and CLDN5, while not expressing PVC markers (Supplementary Fig. 1a–o), thereby confirming the...
Sulfated oligosaccharide activates endothelial Notch for inducing ...
Here, we present a semisynthetic low-molecular sulfated chitosan oligosaccharide (SCOS) that efficiently induces therapeutic arteriogenesis with a spontaneous generation of collateral circulation and blood reperfusion in rodent models of hind limb ischemia and myocardial infarction.
Targeting ESM1 via SOX4 promotes the progression of infantile ...
The SOX4 protein in the nucleus of CD31+ HemECs binds to the downstream target gene ESM1, further activating the PI3K/AKT signaling pathway. This activation promotes the migration and angiogenic behaviors of CD31+ HemECs, facilitating the occurrence and progression of IH.
Esm1 Modulates Endothelial Tip Cell Behavior and Vascular …
2014年7月23日 · We generated and analyzed Esm1 knockout (Esm1 KO) mice to study its role in angiogenesis and inflammation. Esm1 expression is induced by the vascular endothelial growth factor A (VEGF-A) in endothelial tip cells of the mouse retina. Esm1 KO mice showed delayed vascular outgrowth and reduced filopodia extension, which are both VEGF-A–dependent ...
Targeting ESM1 via SOX4 promotes the progression of infantile ...
2024年10月9日 · Results: SOX4 is highly expressed in IH tissues and promotes the proliferation, migration, and angiogenesis of CD31+ HemECs. In addition, SOX4 binds to the endothelial cell-specific molecule 1 (ESM1) promoter to promote the progression of …
苏州大学附属第一医院Jiaoyang, Yang:ESM1与c-Met相互作用通 …
该研究发现,ESM1在胃癌组织中的表达显著上调,并与血小板内皮细胞黏附分子-1(CD31)水平呈正相关。 进一步的临床验证、体外和体内实验证实,ESM1促进胃癌血管生成,最终促进胃癌腹膜转移。 机制上,ESM1通过与血管内皮细胞膜上的c-Met结合来促进肿瘤血管生成。 此外,研究结果证实,ESM1通过激活MAPK/ERK通路上调VEGFA、HIF1α和MMP9的表达并诱导血管生成。 本研究揭示了ESM1在胃癌血管生成和腹膜转移中的作用,为胃癌的诊断和治疗提供了新的思 …
Endothelial Cell-Specific Molecule 1 Promotes Endothelial to ...
We found that ESM1 overexpression resulted in the increased expression of N-cadherin, MMP-9, vimentin and α-smooth muscle actin (α-SMA) and decreased the expression of vascular endothelial cadherin (VE-cadherin) and CD31 in MES 13 cells, compared with control cells . These observations indicate that ESM1 may play an important role in the ...
ESM1 Interacts with c-Met to Promote Gastric Cancer Peritoneal ...
2023年12月30日 · Herein, we demonstrated that ESM1 expression was significantly upregulated in gastric cancer tissues and positively correlated with platelet endothelial cell adhesion molecule-1 (CD31) levels. Moreover, clinical validation, in in vitro and in vivo experiments, confirmed that ESM1 promoted gastric cancer angiogenesis, eventually promoting ...