2025年2月10日 · IHC staining revealed protein expression of ESM1 in KIRC samples. The role of ESM1 in KIRC proliferation and migration were tested by MTT, EdU, transwell analysis. The role of its paracrine...

The goal of this paper is to identify the expression pattern and masked clinical value of ESM1 in CSCC. The IHC assay showed that ESM1 was not expressed or expressed at low levels in control cervical tissues while significantly overexpressed in CSCC. ESM1 protein was widely distributed in the cytoplasm and intercellular stroma of CSCC.

2022年12月15日 · The representative immunohistochemistry (IHC) assay results further verified ESM1 protein upregulation in cervical cancer tissues of Patient#1 (Fig. 1J). Therefore ESM1 is upregulated in...

2023年10月19日 · 我们发现esm1抑制组中的肿瘤体积和重量明显小于载体组（图9a-c），这表明esm1可以促进oc细胞体内的致瘤性。 ihc染色显示esm1抑制可抑制vegf-a、pcna和cdc 25 a的表达（图9d），表明esm1可通过促进增殖、细胞周期和血管生成来加速oc进展。

2010年11月11日 · Moreover, ESM1, IGFBP3 and APELIN mRNA, and ESM-1 protein levels were significantly increased when we subjected human umbilical vein endothelial cells to VEGF treatment (supplemental Figure 4A-C). 25 Taken together, these data illustrate that VEGF positively regulates tip cell gene expression of these secreted molecules.

方法：使用人体标本通过免疫组织化学 (ihc) 检测检测 cscc 中 esm1 的表达，并基于 tnmplot 和 tcga（癌症基因组图谱计划）数据存储库验证和探索 cscc 中的 esm1。

We aimed to study the function and mechanism of endothelial cell-specific molecule 1 (ESM1) in endometrial cancer (EC). The binding relationship between SPI1 and ESM1 was predicted by bioinformatics analysis and verified by the dual-luciferase ...

2022年7月27日 · We further revealed protein expression by immunohistochemistry (IHC), which is related to the prognosis of patients with ESCC using survival analysis. In vitro, knockdown of ESM1 in KYSE150 and KYSE510 cell lines, colony formation assays, wound healing assays, and Transwell assays were performed.

2017年9月30日 · IHC staining of ESM1 is a simple, inexpensive, and reliable method for the analysis of tumor tissues, and is effective in guiding the treatment of hypervascular cancers. Previous studies indicated that ESM1 could be considered as a promising biomarker to assess the prognosis of tumors in the breast 8 , lung 11 , brain 19 , ovary 27 , kidney 24 ...

2023年6月12日 · The IHC assay showed that ESM1 was not expressed or expressed at low levels in control cervical tissues while significantly overexpressed in CSCC. ESM1 protein was widely distributed in the cytoplasm and intercellular stroma of CSCC. In addition, the percentage of ESM1 highly expressed samples in CSCC was 32% (46/145).