2021年8月15日 · In metastatic hormone receptor-positive breast cancer, ESR1 mutations are a common cause of acquired resistance to the backbone of therapy, estrogen deprivation by aromatase inhibition. How these mutations affect tumor sensitivity to established and novel therapies are active areas of research.

2024年12月25日 · ESR1 (Estrogen Receptor 1) is a Protein Coding gene. Diseases associated with ESR1 include Estrogen Resistance and Breast Cancer. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and ESR-mediated signaling.

In this review, we discuss mechanisms of resistance and dissemination of ESR1 mutations, as well as detection methods for ESR1 mutation tracking, newly discovered potential therapeutic targets, and the clinical implications and treatment options for …

Estrogen Receptor alpha（ERα）是核激素受体家族NR3亚家族成员，参与靶细胞的增殖、分化与稳态。 ERα作为经典的核受体，不仅能通过雌激素应答元件（Estrogen Response Elements, ERE）调节靶基因转录，还可结合其他转录因子，如AP-1/c-Jun、 c-Fos、ATF-2等激活转录。 ERα的膜性成分可作为膜性受体，与G蛋白偶联受体家族一起通过第二信使系统发挥转录调控作用。 ERα也是一种有效的非经典 RNA 结合蛋白，调控应激反应基因的转录后表达。 ERα信号转 …

该基因编码雌激素受体和配体激活的转录因子。 经典蛋白包含一个 N 末端配体独立的反式激活结构域、一个中心 DNA 结合结构域、一个铰链结构域和一个 C 末端配体依赖性反式激活结构域。 该蛋白质定位于细胞核，在那里它可能与雌激素受体 2 形成同二聚体或异二聚体。 该基因编码的蛋白质调节许多雌激素诱导基因的转录，这些基因在生长、新陈代谢、性发育、妊娠、和其他生殖功能，并在许多非生殖组织中表达。 由该基因编码的受体在乳腺癌、子宫内膜癌和骨质疏松症中 …

2020年2月3日 · Emerging mutations in the ESR1 gene that encodes for the estrogen receptor (ER) are associated with resistance to endocrine therapy. ESR1 mutations rarely exist in primary tumors (~ 1%) but are relatively common (10–50%) in metastatic, endocrine therapy-resistant cancers and are associated with a shorter progression-free survival.

esr1基因检测的意义主要为：1.提示ai耐药 2.指导临床用药。 提示ai耐药： esr1突变在未接受治疗的原发性乳腺癌患者中发生率较低（<3%），但在晚期乳腺癌患者尤其是曾接受ai治疗的患者中发生率升高（20%~50%）。

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. Down-regulation of ESR1 gene expression was enhanced by the development of the breast cancer.

1 天前 · Seth Wander, MD, PhD, a medical oncologist at the Massachusetts General Hospital and instructor in medicine at Harvard Medical School, discusses the significance of ESR1 mutations in patients with hormone receptor–positive, HER2-negative metastatic breast cancer.. Initially, ESR1 mutations are rare in newly diagnosed patients, occurring in less than 5% of cases.

5 天之前 · The ESR1 gene, encoding estrogen receptor alpha (ERα), is located on chromosome 6 at position 6q25.1. This genomic region plays a key role in hormone signaling and regulation. ESR1 spans approximately 300 kilobases and consists of eight exons, encoding critical receptor domains: the DNA-binding domain (DBD), ligand-binding domain (LBD), and ...