2003年1月6日 · Furthermore, T cell production from ETPs is sustained for longer periods of time when compared with CLPs, further suggesting that they represent a more primitive progenitor population. So, the...

The critical temporal question is whether Notch signaling is activated and required for development of the LMPP, CLP or the ETP. Early insight into the role of Notch in BM T lineage lymphopoiesis can be found in studies which showed that the CLP population expresses Notch1 at the mRNA level, and that Notch1 deficient CLP cells erroneously ...

2024年11月5日 · ETP-ALL and near-ETP-ALL showed similar distribution patterns of hematopoietic stem cell (HSC), lymphoid-primed multipotent progenitors (LMPP), common lymphoid progenitor (CLP), suggesting that these patients arrested at an early thymic developmental stage. GSVA also indicated enrichment of …

2020年11月20日 · 在胸腺中，t细胞的发育以高度结构化的顺序从etp发育而来，其特征是一组特定的表面分子的表达。最早阶段的特征是在成熟的胸腺细胞表面上没有cd3 （cd3包含四条链：cd3γ, cd3δ和两条cd3ε，tcr, ζ-链和cd3组成tcr复合物 ）、cd4和cd8表达，此时成为 双阴性（dn）t细胞。

common lymphoid progenitor (CLP) in bone marrow. The cell commitment of T cells and ILCs appears in the thymus or bone marrow, respec-tively. Downstream of CLPs, the generation of early T cell progenitor (ETP) and the common ILC progenitor (CILCP) initiate the branches of T cell and ILC families, respectively. Lineage choice in

CLP. Instead, the most immature T cell progeni-tors in the CD44+CD25–Linneg pool of cells seg-regated with a Linnegc-kithiIL-7Rαneg/lo phenotype, termed the early T lineage progenitor (ETP) by

急性早期前体t淋巴细胞白血病(etp-all)是2016年世界卫生组织(who)淋巴造血组织肿瘤分类中的独立亚型之一，其具有独特的生物学特征，临床上表现为高度侵袭性，患者长期预后较差。

2016年4月19日 · All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s).

2021年3月16日 · T细胞也是由造血干细胞发育而来，在骨髓内的前期发育过程与B细胞具有共同祖先——普通淋巴祖细胞common lympoid progenitor cell (CLP)。 部分CLP离开骨髓，随血液循环来到胸腺（thymus），即 早期胸腺祖细胞 (Early Thymic Progenitor，ETP)。

Using novel reporter mice, we identified a new subset of early ILC progenitors (EILP) that expressed high amounts of TCF-1. EILP lacked efficient T and B lymphocyte potential, but efficiently gave rise to NK cells and all known adult helper-ILC lineages, indicating that they are the earliest identified ILC-committed progenitors.