2024年5月3日 · Here we found that a well-known oncogene, ETS variant transcription factor 4 (ETV4), serves as a molecular transducer that links mechanical microenvironments and gene expression. In a growing...

2024年12月25日 · ETV4 (ETS Variant Transcription Factor 4) is a Protein Coding gene. Diseases associated with ETV4 include Skeletal Ewing Sarcoma and Hemorrhage, Intracerebral. Among its related pathways are MAPK family signaling cascades and Regulation of activated PAK-2p34 by proteasome mediated degradation.

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors. [5] [6] [7] Disease marker. Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most ...

2024年5月7日 · 研究人员发现一种著名的癌基因——ETS变异转录因子4（ETV4）是连接机械微环境和基因表达的分子换能器。 在人类胚胎干细胞的上皮细胞生长过程中，细胞拥挤动态转化为ETV4的表达，成为未来细胞谱系命运的前模式。 在人类胚胎干细胞上皮细胞中，类似开关的ETV4因细胞拥挤而失活，从而抑制了神经外胚层分化的潜力。 从机理上讲，细胞拥挤会使整合素-肌动蛋白通路失活，并阻断成纤维细胞生长因子受体（FGFR）的内吞。 成纤维细胞生长因子 …

ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification. An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression. ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.

2023年4月5日 · We generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and higher protein dosage through mutation of its degron.

2025年2月8日 · Title: Identification and characterization of novel ETV4 splice variants in prostate cancer. ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.

2023年9月5日 · ETV4 promoted hepatic inflammation and HCC by activating transcription of TNF-α and MAPK11. Both the ETV4/TNF-α and ETV4/MAPK11 axes represented two potential therapeutic targets for highly associated hepatic inflammation and HCC. ETV4+TNF-α were potential prognostic markers for HCC patients.

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of keratinocyte differentiation and positive regulation of …

2021年12月28日 · ETS variant 4 (ETV4) has been implicated in the development of various cancers. However, the molecular events mediated by ETV4 in liver cancer are poorly understood, especially in hepatitis B virus (HBV)-associated liver hepatocellular carcinoma (LIHC). Here, we aimed to identify the target involved in ETV4-driven hepatocarcinogenesis.