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GeneCards
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ETV6 Gene - GeneCards | ETV6 Protein | ETV6 Antibody
ETV6 (ETS Variant Transcription Factor 6) is a Protein Coding gene. Diseases associated with ETV6 include Thrombocytopenia 5 and Hematologic Cancer. Among its related pathways are Signaling by PDGFR in disease and FLT3 signaling in disease.
ETV6 - Wikipedia
ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is enc…
Wikipedia
ETV6 Thrombocytopenia and Predisposition to Leukemia
The diagnosis of ETV6 thrombocytopenia and predisposition to leukemia is established in a proband by identification of a heterozygous germline pathogenic …
National Center for Biotechnology Information
ETV6 ETS variant transcription factor 6 [ (human)]
ETV6 Regulates Hemin-Induced Erythroid Differentiation of K562 Cells through Mediating the Raf/MEK/ERK Pathway. ETV6-NCOA2 fusion induces …
National Center for Biotechnology Information
What does ETV6 stand for?
Complete information for ETV6 gene (Protein Coding), ETS Variant Transcription Factor 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
genecards.org
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etv6 abl
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Wikipedia
https://en.wikipedia.org › wiki
ETV6 - Wikipedia
Inherited Mutations
Acquired Mutations
Solid Tumors
Rare missense and other loss of function mutations in ETV6 cause thrombocytopenia 5, an autosomal dominant familial disease characterized by variable thrombocytopenia (blood platelet counts from 5% to 90% of normal), mild to modest bleeding tendencies, and bone marrow biopsy findings of abnor…
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › books
ETV6 Thrombocytopenia and Predisposition to Leukemia
2020年11月19日 · The diagnosis of ETV6 thrombocytopenia and predisposition to leukemia is established in a proband by identification of a heterozygous germline pathogenic variant in …
- 作者: Christopher C Porter, Jorge Di Paola, Bojana Pencheva
- 已发布: 2020/11/19
- Publish Year: 2020
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
ETV6 ETS variant transcription factor 6 [ (human)]
ETV6 Regulates Hemin-Induced Erythroid Differentiation of K562 Cells through Mediating the Raf/MEK/ERK Pathway. ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia …
yiigle.com
https://rs.yiigle.com
ETV6-RUNX1融合基因阳性儿童急性前体B淋巴细胞白血病的临床特 …
根据etv6-runx1检测结果，分为etv6-runx1 + 组及etv6-runx1-组，对比两组的临床特征及预后；182例etv6-runx1 + 患儿规范治疗，其中144例接受中国儿童白血病协作组（cclg）-all 2008 …

知乎专栏
https://zhuanlan.zhihu.com
Nat Cell Bio | 免疫与发育关键调节基因ETV6可成为肿瘤 …
2023年2月2日 · etv6(又称tel)基因，位于染色体12p13，编码一种 ets家族的转录因子。etv6基因是一种肿瘤抑制基因，在造血和血管网络发育、维持中起着重要作用。 ETV6基因是一种肿瘤抑制基因，在造血和血管网络发育、维持中起着重 …
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What is ETV6 protein?
ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues.
ETV6 - Wikipedia
en.wikipedia.org
What diseases are associated with ETV6?
Diseases associated with ETV6 include Thrombocytopenia 5 and Hematologic Cancer. Among its related pathways are Signaling by PDGFR in disease and FLT3 signaling in disease. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding.
ETV6 Gene - GeneCards | ETV6 Protein | ETV6 Antibody
genecards.org
What does ETV6 stand for?
Complete information for ETV6 gene (Protein Coding), ETS Variant Transcription Factor 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
ETV6 Gene - GeneCards | ETV6 Protein | ETV6 Antibody
genecards.org
What is ETV6 (Ets variant transcription factor 6)?
ETV6 (ETS Variant Transcription Factor 6) is a Protein Coding gene. Diseases associated with ETV6 include Thrombocytopenia 5 and Hematologic Cancer. Among its related pathways are Signaling by PDGFR in disease and FLT3 signaling in disease.
ETV6 Gene - GeneCards | ETV6 Protein | ETV6 Antibody
genecards.org
What does ETV6 encode?
ETV6 encodes transcription factor ETV6. There are three main domains: ETV6 is a repressor of transcription, with critical roles in embryonic development and hematopoietic regulation [Hock et al 2004]. ETV6 is highly expressed in hematopoietic progenitor cells and is essential for hematopoiesis in the bone marrow [Di Paola & Porter 2019].
ETV6 Thrombocytopenia and Predisposition to Leukemia
ncbi.nlm.nih.gov
What chromosomal rearrangements are associated with ETV6?
This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] ETV6 (ETS Variant Transcription Factor 6) is a Protein Coding gene. Diseases associated with ETV6 include Thrombocytopenia 5 and Hematologic Cancer.
ETV6 Gene - GeneCards | ETV6 Protein | ETV6 Antibody
genecards.org
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知乎专栏
https://zhuanlan.zhihu.com
Nature immunology| 转录抑制子ETV3和ETV6调控单核 …
聚焦这个问题，作者发现转录抑制子etv3和etv6控制人单核细胞向树突状细胞分化（mo-dcs）。etv3和etv6抑制干扰素（ifn）刺激基因表达；然而，它们对单核细胞分化的作用是独立于ifn信号的。相反，我们发现etv3和etv6通过控制mafb的 …
PubMed
https://pubmed.ncbi.nlm.nih.gov
ETV6 in hematopoiesis and leukemia predisposition - PubMed
The ETV6 (also known as TEL) gene encodes a transcriptional repressor that plays a critical role in hematopoiesis and in embryonic development. While somatic ETV6 translocations and …
Nature
https://www.nature.com › articles
The ETS transcription factor ETV6 constrains the ... - Nature
2023年1月19日 · Independent but complementary studies from Vakoc and Stegmaier identify and characterize a role for ETV6 in counteracting the transcriptional activity of EWS–FLI during …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Acute myeloid leukemia carrying ETV6 mutations: biologic and …
Objectives: E26 transformation-specific variant 6 gene (ETV6) is one of the most consistently rearranged genes in acute leukaemia. It encodes a principal hematopoietic transcription factor. …
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