While EAAT3 is traditionally described as the neuronal carrier in glutamatergic synapses, this view is currently being challenged and it is now generally agreed that EAAT3 is found in most …

Excitatory amino acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons.

The EAATs can transport (S)-Glu, (S)-Aspartate (Asp) and (R)-Asp, cysteic acid, and serine-O-sulfate. EAAT3 can also efficiently transport (R)-Cys at physiologically relevant conditions. It …

2016年5月29日 · 它也是主要的神经元半胱氨酸摄取系统，是表达EAAT3的神经元中谷胱甘肽（一种有效的抗氧化剂）合成的限速因子，而在GABA能神经元上，它对提供谷氨酸作为GABA合 …

2019年11月13日 · Na +依赖性兴奋性氨基酸转运蛋白（EAAT）是中枢神经系统（CNS）中细胞外谷氨酸去除的主要转运机制。 分配给EAAT的主要功能是维持低的细胞外谷氨酸水平，从而使 …

2024年9月5日 · Among five EAATs, EAAT3 is the only isoform that can efficiently transport L-cysteine, a substrate for glutathione synthesis. Recent work suggests that EAAT3 also …

2024年9月5日 · EAAT3, an electrogenic acidic amino acid and cysteine transporter, orchestrates amino acid metabolism and protects cells from oxidative stress. Our structures visualize …

EAAT3是啮齿动物兴奋性氨基酸载体1（EAAC1）的人类对应物，由SLC1A1编码基因。 EAAT3 / EAAC1在大脑中普遍存在，主要在神经元中表达，但在其他细胞类型中也表达，例如少突胶 …

2021年3月4日 · Human excitatory amino acid transporter 3 (hEAAT3) mediates glutamate uptake in neurons, intestine, and kidney. Here, we report cryo-EM structures of hEAAT3 in several …

2019年3月5日 · We show that SorCS2 acts as sorting receptor that sustains cell surface expression of the neuronal amino acid transporter EAAT3 to facilitate import of cysteine, …