2025年2月22日 · To shed light on the regulatory mechanism of EAAT3 in lung cancer, we postulated a plausible hypothesis implicating the NF-κB signaling pathway in EAAT3 …

2025年2月22日 · In this study, we conducted a comprehensive reanalysis of publicly available data and employed the Gprc5a-/-/SR-IκB mouse model alongside in vitro cell experiments to …

NF-κB drives EAAT3 expression, key for GSH biosynthesis in lung cancer cells. EAAT3 knockdown increases ROS and enhances sensitivity to ferroptosis in lung cancer.

2025年2月23日 · 为解决肺癌中 EAAT3 上调机制不明及探寻潜在治疗策略问题，研究人员开展 NF-κB 与 EAAT3 相关性研究，发现 NF-κB/EAAT3 轴影响肺癌发展。 该研究为肺癌治疗提供新思 …

Our prior research established that the uptake of glutamate via EAAT3 plays a pivotal role in driving cystine uptake through xCT, contributing to GSH biosynthesis during lung …

2025年2月22日 · Our prior research established that the uptake of glutamate via EAAT3 plays a pivotal role in driving cystine uptake through xCT, contributing to GSH biosynthesis during lung …

2024年11月26日 · EAAT3: EAAT3，也称为EAAC1或SLC1A1，是大脑中的“神经元”谷氨酸转运蛋白，主要位于轴突末端和大脑皮层、海马、纹状体和基底节的树突（Escobar等人，2019）。 …

EAAT3 internalization results in potentiation of glutamate receptor responses in midbrain dopamine neurons primarily due to activation of NMDA receptors containing NR2B subunits …

In a study across a panel of cancer types including breast, colon and lung cancer, EAAT1-mediated aspartate uptake was correlated with resistance to inhibition of the electron transport …

Furthermore, our investigation unveiled the upregulation of EAAT3 in a subset of clinical non-small cell lung cancer (NSCLC) tissues, exhibiting a positive correlation with the P65 protein. …