2019年8月7日 · Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +, CD8 + and γδ + T cells in the blood...

在eae中，mog诱导cd4或cd8缺陷的eae小鼠cns的病灶是由cd8 + t细胞造成的；同样与野生型动物相比，mog1-125诱导在cd8缺陷dba/1的eae小鼠中可发现脱髓鞘和cns炎症的减少。

2019年10月1日 · Here, we investigated whether naive MBP-specific CD8 + T cells recruited to the CNS during CD4 + T cell–initiated EAE engaged in determinant spreading and influenced disease. We found that the MBP-specific CD8 + T cells exacerbated brain but …

2021年10月29日 · Our data indicate that AE-specific CD8 + T cells accumulate in the CNS of mice with EAE where they actively contribute to disease exacerbation. We have previously shown a higher frequency of...

Regulators to the rescue 一种被称为CD8 T细胞的免疫细胞通常杀死致病因子，现已发现它能抑制自身反应性免疫细胞，从而对小鼠自身免疫性疾病提供保护。 作者：HYE-JUNG KIM & HARVEY CANTOR 免疫系统已经进化…

2025年2月28日 · We previously demonstrated that adoptively transferred myelin-reactive CD8 + T cells (PLP-CD8) prevent EAE induction and suppress ongoing disease through the engagement of MHC Class-I in recipient mice. Here, we show that PLP-CD8 induce regulatory changes in both subsets of conventional dendritic cells (cDC1 and CD11b + cDC) in vivo and in vitro.

2018年6月27日 · Our data suggest a novel therapeutic nanoparticle to directly modulate autoreactive T cells by surface presentation of multiple ligands and paracrine release of cytokine in the antigen-specific combination immunotherapy for T cell-mediated autoimmune diseases.

Polymerase chain reaction analysis suggested that both CD4 (+) and CD8 (+) T cells produced IFN-gamma and TNF-alpha, while CD4 (+) T cells also produced interleukin-17 (IL-17), an important factor in the development of EAE. Thus, CD4 (+) T cells may contribute to the induction of EAE by producing IL-17.

2009年8月8日 · Overall, our findings support a moderately pathogenic role for MOG37-46 CD8+ T cells and show a significant disease enhancement and sustained inflammation in the presence of CD4+ T cells. Alone, CD8+ T cells induce mild EAE and addition of exogenous MOG-specific CD8+ T cells results in minor increase of disease symptoms (Fig. 7). Interestingly ...

结果:MOG35-55诱导的EAE模型组动物出现典型的EAE临床行为学及病理学表现,进行CD8/Glut-1/DAPI和CD4/Glut-1/DAPI染色,检测到CD8细胞和CD4细胞发病高峰期在脊髓中有显著地浸润,在中枢的表达均高于外周,对照组中枢神经系统未检测到淋巴细胞浸润.FCM检测EAE模型组小鼠活化的CD4细胞在整个病程中均有显著升高,而活化的CD8细胞在疾病早期有显著的抑制,在病程晚期有显著的活化作用.CD3总细胞群在发病过程中和对照组相比数量显著下降,单核巨噬细胞相对百分 …