EBF1 stands for Early B-Cell Factor 1. [5] [6] [7] EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function. [8] [9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells. [10]

2024年12月24日 · EBF1 (EBF Transcription Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include Leukemia, Acute Lymphoblastic 3 and Leukemia, Acute Lymphoblastic. Among its related pathways are Olfactory Signaling Pathway and Transcriptional regulation of white adipocyte differentiation.

2024年12月28日 · 本文将详细介绍EBF1基因的功能、作用机制、信号通路以及与疾病的关系，帮助读者全面理解这一关键基因在生物学中的重要性。 EBF1基因的基本信息 EBF1，全称为Early B-cell factor 1 ，是一个位于染色体5q33.3的基因，编码一个具有蛋白质产物的转录因子。这个基因也被称为OLF1 或COE1 ，在生物学研究中有 ...

ebf 转录因子 1： 预测可实现 dna 结合转录激活因子活性、rna 聚合酶 ii 特异性和 rna 聚合酶 ii 顺式调节区序列特异性 dna 结合活性。 预测参与 RNA 聚合酶 II 对转录的正调控。

2010年5月28日 · The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage specification and differentiation. To gain insight into the molecular basis of Ebf1 function in early-stage B cells, we combined a genome-wide ChIP sequencing analysis with gain- and loss-of-function transcriptome analyses.

2013年12月13日 · EBF1 plays a crucial role in early adipogenesis; however, despite high expression in mature adipocytes, its function in these cells is currently unknown. To identify direct and indirect EBF1 targets in fat, we undertook a combination of transcriptional profiling of EBF1-deficient adipocytes and genome-wide EBF1 location analysis.

日前，德国马克思普朗克免疫生物学和表观遗传学研究所的研究人员发现，转录因子 EBF1 对于 B 细胞记住自身的身份起至关重要的作用。 当研究人员关闭这一转录因子时，细胞会失去从前的特性，发育成 T 细胞。 这一研究发现发表在近期的《自然免疫学》（Nature Immunology）杂志上。 从干细胞转变为免疫系统的功能组成部分，细胞必须要经历一些特化阶段，在这些阶段它们有机会在导致血液中各种细胞类型生成的信号通路之间做出选择。 而同样极为重要的是，一旦它们做 …

early B cell factor-1 (EBF1) was identified as a co-regulator of gene expression with MEF2C. Epstein-Barr Virus EBNA1 bound to host genes of high significance for B-cell growth and function, including MEF2B, IL6R, and EBF1.

2024年1月31日 · Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Genome-wide association analyses identify variants in developmental genes associated with hypospadias.

The onset of B cell differentiation is initiated by Early B cell Factor 1 (EBF1, also known as EBF/COE1/O/E−1). Although many important transcription factors, including PU.1, Ikaros, and E2A, are expressed before EBF1 and prepare cells for the B cell fate, it is EBF1 that drives B cell specification and commitment (see section on Regulation ...