2018年2月20日 · The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B …

2018年2月20日 · We have investigated the role of an EBV protein (EBNA-LP) which is thought to support gene activation by the essential virus protein EBNA2. We have made an EBV in which …

2015年1月23日 · Latent EBV genomes express five EBV-encoded nuclear antigens (EBNA) and two latent membrane proteins (LMPs), namely EBV-encoded small RNA (EBER) and non …

2023年8月18日 · EBNA-LP does not simply co-operate with EBNA2 in activating gene transcription, but rather facilitates the recruitment of several transcription factors to the viral …

2024年7月31日 · EBV induced cellular transformation is driven by viral proteins including EBV-Nuclear Antigens (EBNAs). EBNA-LP is important for the transformation of naïve but not …

The genome of Epstein-Barr virus (EBV), a gammaherpesvirus with potent B-cell growth-transforming ability, contains multiple copies of a 3-kb BamHI W repeat sequence; each repeat …

2024年7月31日 · We developed a trans-complementation assay wherein transfection with wild-type EBNA-LP rescues the transformation of peripheral blood- and cord blood-derived naïve B …

2019年9月2日 · The locations of the latent EBV genes encoding Epstein–Barr nuclear antigen (EBNA) leader peptide (EBNA-LP), EBNA2, EBNA3A–EBNA3C and EBNA1 as well as latent …

2013年10月1日 · Epstein–Barr virus (EBV) nuclear antigens EBNALP (LP) and EBNA2 (E2) are coexpressed in EBV-infected B lymphocytes and are critical for lymphoblastoid cell line …

The Epstein-Barr virus (EBV) EBNA-LP and EBNA2 proteins are the first to be synthesized during establishment of latent infection in B lymphocytes. EBNA2 is a key transcriptional regulator of …