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2024年4月23日 · In this work, we show the feasibility of integrating an oxygen-carrying nanobubble, EBO, into a wound dressing to facilitate therapeutic exosome delivery by incorporating an antioxidative and...

2024年5月8日 · 近日，美国伊利诺伊大学厄巴纳-香槟分校Joseph Irudayaraj教授团队最新成果发表于Nature Communications 期刊，论文主要研究了一种新型的多功能水凝胶（EBO-Gel），它能够增强外泌体（exosomes）的细胞内递送，从而加速伤口愈合。

本研究展示了这种多功能水凝胶在雄性大鼠全厚伤口模型中增强愈合、促进血管生成、促进外泌体输送、缓解缺氧和抑制炎症的潜力。 相关工作以题为 “Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing” 的文章发表在2024年04月23日的国际顶级期刊 《Nature Communications》。 1. 创新型研究内容. 为进一步优化伤口敷料的止血和抗氧化性能，本研究将聚乙烯醇（PVA）、明胶（GA）和 硼砂 结合在一 …

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2024年6月18日 · EBO-Gel的无疤痕愈合潜力归因于ADSC-Exos的多方面功能，富含调节纤维化反应和瘢痕疙瘩成纤维细胞迁移的microRNA（图6）。 此外，EBO-Gel 在解决缺氧性增生性疤痕中的异常代谢方面显示出前景，为进一步研究疤痕管理提供了一条有希望的途径。

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