El potencial efecto protector de la ECA2 ha promovido el desarrollo de un estudio que evalua el beneficio del tratamiento con ECA2 recombinante en pacientes con COVID-19 (Clinicaltrials.gov; NCT04287686). Su capacidad de disminuir la activación pulmonar del SRAA y atenuar la respuesta inflamatoria podría reducir la gravedad de la enfermedad.

2022年4月20日 · In this review, we summarize the diverse roles of ACE2, highlighting its role as the SARS-CoV-2 receptor and negative regulator of the RAS, and the implications for the COVID-19 pandemic. We also provide a framework for developing novel therapeutic strategies exploring the ACE2 pathway as it relates to CVD and COVID-19.

2020年6月29日 · Accumulating evidence now suggests that genetic polymorphisms in the ACE2 gene may modulate intermolecular interactions with the spike protein of SARS-CoV-2 and/or contribute to pulmonary and systemic injury by fostering vasoconstriction, inflammation, oxidation and …

2022年3月8日 · Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies...

2023年10月1日 · O coronavírus SARS-CoV-2, causador da pandemia de COVID-19, infecta as células através da ligação com a Enzima Conversora de Angiotensina 2 (ECA2), presente na superfície celular. Essa interação resulta na regulação negativa da enzima, prejudicando a conversão da Angiotensina II, produzida pela enzima homóloga ECA, em Angiotensina 1-7.

Com ênfase nos mecanismos moleculares e fisiopatológicos subjacentes, discorreremos sobre os potenciais fatores de risco que podem contribuir para a gravidade da COVID-19 em pacientes com idade avançada: alterações da ECA2 (enzima conversora da angiotensina 2), imunossenescência e inflammaging, e presença de multimorbidade e fragilidade.

2020年7月13日 · An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in …

2020年6月16日 · However among children, COVID-19 severity differs in relation to age, and severe disease can develop in children younger than 4 years, particularly in infancy, the age group with the highest rate of hospitalization among children with COVID-19 (3). In addition, among children, the rate of severe or critical illness in those aged 1 to 5 years ...

Estudos recentes demonstraram aumento da expressão da ECA-2 no epitélio de pequenas vias respiratórias de tabagistas e portadores de DPOC com COVID-19. Brake et al., 24 por meio da imuno-histoquímica, identificaram pela primeira vez uma expressão aumentada de ECA-2 no tecido pulmonar de pacientes com COVID-19.

Assuming ACE2 internalization is the trigger for COVID-19 pathogenesis, accumulation of angiotensin II can be viewed as the potential cause of symptoms. Angiotensin II is a strong vasoconstrictor, but has also important roles in hypertrophy, inflammation, remodeling, and …