The Dyno eCap 1 capsid achieves highly efficient transduction of of bipolar cells, enabling optogenetic therapeutic interventions in advanced retinal disease progression. Cell-specific co-staining of regions of transduction in the central (nonmacula) NHP retina, injected at …

2023年10月25日 · The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. The Dyno eCap 1 vector was validated in cynomolgus monkey (Macaca fascicularis), the most relevant NHP model for predicting translatability to human clinical trials. Improved performance is highly ...

2023年10月25日 · The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. Dyno eCap 1载体始终在视网膜层广泛转导细胞类型，包括视杆细胞，双极细胞和视网膜神经节细胞。

2023年10月30日 · Per Dyno, the Dyno eCap 1 capsid is essentially designed to provide significantly improved delivery (vs other externally engineered capsids) to the eye, including transduction throughout multiple layers of the retina.

2020年2月22日 · 最近看到Windows 10 预览版推送新图标了，所以提取了下，给老旧的Ecap换了换界面。 顺便换掉了“咔嚓”声音和部分文字。 运行程序后会自动在开始菜单添加快捷方式， ...

Dyno - Dyno Therapeutics

2023年10月26日 · The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. The Dyno eCap 1 vector was validated in cynomolgus monkey ( Macaca fascicularis ), the most relevant NHP model for predicting translatability to human clinical trials.

2023年10月25日 · The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. The Dyno eCap 1 vector was validated in cynomolgus monkey (Macaca fascicularis), the most relevant NHP model for predicting translatability to human clinical trials. Improved performance is highly ...

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Here we characterize the Dyno eCap 1 capsid, a novel capsid designed with generative AI leveraging in vivo data from multiplexed measurements of capsid libraries.