EDEM1 Gene - GeneCards | EDEM1 Protein | EDEM1 Antibody
2024年12月24日 · EDEM1 (ER Degradation Enhancing Alpha-Mannosidase Like Protein 1) is a Protein Coding gene. Diseases associated with EDEM1 include Albinism, Oculocutaneous, …
Mannosidase activity of EDEM1 and EDEM2 depends on an …
2018年10月18日 · To better understand the role of EDEM1 in the removal of mannose residues from misfolded N-linked glycoproteins and their targeting to ERAD, we analyzed directly the …
EDEM1 ER degradation enhancing alpha-mannosidase like protein …
EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired. A somatic variant of EDEM1 (N198I) alters ATF6 …
EDEM1 Drives Misfolded Protein Degradation via ERAD and ... - PubMed
2020年5月14日 · ER-degradation enhancing α-mannosidase-like (EDEM1) was proposed to extract terminally misfolded proteins from the calnexin folding cycle and target them for …
ER 降解增强α-甘露糖苷酶样蛋白 1（EDEM1）基因 | MCE
Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Involved in mannose trimming involved in glycoprotein ERAD pathway; positive …
EDEM1 Drives Misfolded Protein Degradation via ERAD and …
2020年5月14日 · ER-degradation enhancing α-mannosidase-like (EDEM1) was proposed to extract terminally misfolded proteins from the calnexin folding cycle and target them for …
EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism …
2021年12月23日 · Endoplasmic reticulum (ER) degradation-enhancing α-mannosidase-like protein 1 (EDEM1) is a quality control factor directly involved in the endoplasmic reticulum …
Identification of EGF Receptor and Thrombospondin-1 as …
2023年7月29日 · EDEM1 exhibits mannose-trimming activity of N-glycans and presents misfolded proteins following interaction with downstream ERAD factors, such as OS-9 and XTP3B …
Turnover of EDEM1, an ERAD-enhancing factor, is mediated by
EDEM1 is an ERAD-accelerating factor whose gene expression is upregulated by the accumulation of aberrant proteins in the ER, known as ER stress. Although the role of EDEM1 …
Targeting EDEM protects against ER stress and improves ... - PLOS
2022年2月22日 · We found that EDEM-2 has a major role in the clearance of misfolded proteins from ER under physiological conditions, whereas EDEM-1 and EDEM-3 roles become …