2024年12月24日 · EDNRB (Endothelin Receptor Type B) is a Protein Coding gene. Diseases associated with EDNRB include Waardenburg Syndrome, Type 4A and Abcd Syndrome. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET 1, ET 2, and ET 3.

ednrb蛋白是内皮素1（edn1）、内皮素2（edn2）和内皮素3（edn3）的非特异性受体。通过与g蛋白结合，ednrb能够激活磷脂酰肌醇-钙第二信使系统，从而在介导内皮素神经肽引发的细胞反应中发挥关键作用。这一机制强调了ednrb在转导各种生理过程信号中的多功能性。

该基因编码的蛋白质是一种 G 蛋白偶联受体，可激活磷脂酰肌醇-钙第二信使系统。 其配体内皮素由三种有效的血管活性肽家族组成：ET1、ET2 和 ET3。 研究表明，多基因疾病 2 型先天性巨结肠是由内皮素受体 B 型基因突变引起的。 可变剪接和替代启动子的使用会导致多种转录本变体。 [RefSeq 提供，2016 年 10 月] The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system.

The findings provide strong evidence for the first time that knockdown of EDNRB expression inhibits the progression of triple-negative breast cancer and that EDNRB can serve as a prognostic biomarker and therapeutic target for the treatment of triple-negative breast cancer.

1999年12月2日 · Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice...

2024年8月22日 · Here, we show the role of endothelin 3 (EDN3) and endothelin receptor type B (EDNRB) in promoting the browning of white adipose tissue (WAT). EDNRB overexpression stimulates thermogenic...

The EDNRB gene provides instructions for making a protein called endothelin receptor type B. This protein is located on the surface of cells and functions as a signaling mechanism, transmitting information from outside the cell to inside the cell.

HGNC Approved Gene Symbol: EDNRB. Endothelins belong to a family of potent vasoactive peptides consisting of 3 isopeptides, ET1 (EDN1; 131240), ET2 (EDN2; 131241), and ET3 (EDN3; 131242). A diverse set of pharmacologic activities with different potencies are exerted by endothelin family peptides, suggesting the existence of ET receptor subtypes.

It encodes a receptor for endothelins, Peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes.