Lower Ea results in an increased stroke volume and lower systolic blood pressure, whereas raising Ea results in the opposite effect. While ESPVR and EDPVR form the basis of PV loop analysis and interpretation and can be used to describe specific aspects of ventricular function, interpretation of each parameter in isolation has limitations.

2017年2月28日 · Diastolic dysfunction, which is the key pathophysiological mechanism in HFpEF, is also considered a potential pathophysiological factor of HFrEF. 23 In the present study, EDPVR normalization was significantly associated with higher CO regardless of EF in high‐EDP patients.

2025年1月1日 · The steeper EDPVR in HFpEF compared to HFrEF is important to note in the development of novel MCS devices for this patient group, particularly with respect to ventricular volume capacity and the requirement for pressure unloading.

2016年6月14日 · We estimated the position of the EDPVR and its stiffness-coefficient β from echocardiographic data using a single-beat method. The EDPVR was shifted rightward in HFrEF and leftward in HFpEF compared with 'No HF', while the stiffness-coefficient β was increased in both HFrEF and HFpEF.

舒张末期压力-容量关系（EDPVR） 的斜率通常被认为是 心室顺应性（compliance）的倒数（也即弹性 （elastance，弹性与顺应性是相反的概念））。 在正常情况下，心室顺应性较大，因此斜率较小，当容积过大时出现顺应性下降而增大斜率。 心室顺应性发生变化时即可见EDPVR曲线的上移与下移。 病理条件下，当心室顺应性下降时，就可能出现 心室舒张功能障碍，也即 舒张性心力衰竭。 如 心肌肥厚、心室松弛受损 等，均会导致顺应性下降，产生 上移 的EDPVR。 这通常 …

2024年9月1日 · Recent clinical studies have reported that heart failure with preserved ejection fraction (HFpEF) can be divided into two phenotypes based on the range of ejection fraction (EF), namely HFpEF with higher EF and HFpEF with lower EF. These phenotypes exhibit distinct left ventricle (LV) remodelling patterns and dynamics.

2016年4月19日 · Cardiac magnetic resonance (CMR)–derived T 1 mapping can noninvasively quantify diffuse myocardial fibrosis as extracellular volume fraction (ECV). This study aimed to elucidate the diagnostic performance of T 1 mapping in HFpEF by examining the relationship between ECV and invasively measured parameters of diastolic function.

2021年10月18日 · An ideal, purely hemodynamic treatment for HFpEF would move filling toward lower diastolic pressures without sacrificing too much of the EDV. A perfect treatment would move EDV to the point where the EDPVR is just beginning to become exponential, which may further benefit from controlled eccentric remodeling.

Patients with HFpEF ≥65% displayed an end-diastolic pressure-volume relationship (EDPVR) that was shifted leftward, with increased LV diastolic stiffness constant β, in both invasive and community-based cohorts.

2015年11月15日 · Myocardial stiffness and upward-shifted end-diastolic pressure-volume (P-V) relationship (EDPVR) are the key to high filling pressures in heart failure with preserved ejection fraction (HFpEF). Nevertheless, many patients may remain asymptomatic unless hemodynamic stress is imposed on the myocardium …