Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene. [5] [6] This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha ...

2024年12月24日 · EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14 and Lice Infestation. Among its related pathways are Peptide chain elongation and Infectious disease.

2015年5月1日 · eEF1A1 主要是在蛋白质合成中起到呈递氨基 酰-tRNA 的作用，但有研究发现eEF1A1 可以与细胞骨架 蛋白结合，通过与骨架蛋白相互作用而发挥生物学功能。

2025年2月20日 · The eEF1A1/ARID3A/PKC-δ complex critically regulates macrophage glycolytic reprogramming in atherosclerosis by mediating ARID3A phosphorylation and nuclear translocation, thereby driving ENO2 transcr...

2015年4月7日 · Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer, and lung cancer. eEF1A1 modulates cytoskeleton, exhibits chaperone-like activity an …

2014年9月16日 · Translation elongation factor eEF1A has a well-defined role in protein synthesis. In this study, we demonstrate a new role for eEF1A: it participates in the entire process of the heat shock response (HSR) in mammalian cells from transcription through translation.

eEF1A1 is a novel endothelial nitric oxide synthase 3'-untranslated region binding protein that plays a critical role in mediating tumor necrosis factor (TNF)-alpha-induced decrease in eNOS mRNA stability.

Eukaryotic elongation factor 1A1 (EEF1A1) is canonically involved in protein synthesis but also has noncanonical functions in diverse cellular processes. Previously, we identified EEF1A1 as a mediator of lipotoxicity and demonstrated that chemical inhibition of EEF1A1 activity reduced mouse liver li …

2025年2月8日 · The cell death was associated with downregulation of eukaryotic translation elongation factor-1 alpha 1 (eEF1A1/EF-1alpha) expression in conjunction with accumulation of its mRNA in processing bodies (P bodies). both eEF1A and MYPT1 have roles in EGCG signaling for cancer prevention through 67LR

该基因编码延伸因子 1 复合物的 alpha 亚基的亚型，负责将氨酰 tRNA 酶促递送至核糖体。 这种亚型 (α 1) 在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型 (α 2) 在脑、心脏和骨骼肌中表达。 在 66% 的 Felty 综合征患者中，这种亚型被确定为自身抗原。 已发现该基因在许多染色体上有多个拷贝，其中一些 (如果不是全部的话) 代表不同的假基因。 [RefSeq 提供，2008 年 7 月]