2023年12月16日 · Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in various biological tissues, including the kidney, lung, and colon. They enable the selective reabsorption of sodium ions, which is a process critical for controlling blood pressure, electrolyte balance, and overall fluid volume.

2021年1月25日 · ENaC (epithelial sodium channel) is one of the key transporters responsible for the reabsorption of sodium in the distal nephron. This channel has an important role in the regulation of extracellular fluid volume and consequently blood pressure.

2015年12月15日 · Amiloride-sensitive epithelial sodium (Na +) channels (ENaCs) play a crucial role in Na + transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ.

The epithelial sodium channel (ENaC) is the rate-limiting step for sodium reabsorption across tight epithelia. Cyclic-AMP (cAMP) stimulation promotes ENaC trafficking to the apical surface to increase channel number and transcellular Na+ transport. ...

Control of hypertension and correction of hypokalemia can be achieved with the administration of large doses of ENaC blockers (amiloride or triamterene) but not with aldosterone receptor blockers (e.g., spironolactone). The effect of ENaC blockers is more evident in patients who are on a salt-restricted diet. Stuart M. Brierley, ...

2020年1月7日 · ENaCs are activated by specific proteases in the biosynthetic pathway and at the cell surface and remove embedded inhibitory tracts, which allows channels to transition to higher open-probability states. Resolved structures of ENaC and an acid-sensing ion channel revealed highly organized extracellular regions.

2023年3月1日 · The epithelial Na + channel (ENaC) is a Na + selective and non–voltage-gated channel blocked by low concentrations of amiloride. ENaC expression has been detected on the apical membrane of epithelial cells in organs including kidney, lung, colon, sweat and salivary glands, lingulae, and the reproductive tract.

2018年9月25日 · The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na + and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel. Here, we present the structure of human ENaC in the uncleaved state determined by single-particle cryo-electron ...

2021年12月9日 · The epithelial sodium channel (ENaC) plays a key role in salt and water homeostasis in tetrapod vertebrates. There are four ENaC subunits (α, β, γ, δ), forming heterotrimeric αβγ- or δβγ-ENaCs. Although the physiology of αβγ-ENaC is well understood, for decades the field has stalled with respect to …

The ENaC 2 has evolved as a channel that is thought to reside primarily in an active state, facilitating the bulk movement of Na + out of renal tubular or airway lumens. The regulated insertion and retrieval of channels at the plasma membrane have important roles in modulating ENaC-dependent Na + transport (1).