The epitope EFRH, corresponding to amino acids 3–6 within the human β-amyloid peptide (AβP), acts as a regulatory site controlling both the formation and disaggregation process of the β …

In the present study we have found that phage displaying high EFRH copy number are effective in eliciting humoral response against the EFRH sequence, which in turn relieves the amyloid …

2000年10月10日 · The epitope EFRH, corresponding to amino acids 3–6 within the human β-amyloid peptide (AβP), acts as a regulatory site controlling both the formation and …

1998年8月1日 · Among 44 positive phage-clones, selected from the library by both antibodies, 40 clones carried the consensus sequence EFRH. These EFRH phage-clones bind specifically …

1998年8月1日 · These findings confirm that the peptide EFRH which is located at positions 3–6 within β -amyloid peptide represents the sequential epitope of mAbs 6C6 and 10D5. 1. …

The epitope EFRH, corresponding to amino acids 3-6 within the human beta-amyloid peptide (AbetaP), acts as a regulatory site controlling both the formation and disaggregation process …

2007年1月30日 · Here we show that anti-EFRH immunotherapy of a platelet-derived amyloid precursor protein transgenic mouse model of AD stimulates endogenous neurogenesis, …

2000年10月10日 · The epitope EFRH, corresponding to amino acids 3-6 within the human beta-amyloid peptide (AbetaP), acts as a regulatory site controlling both the formation and …

1999年3月1日 · The EFRH peptide strongly inhibits binding of mAbs 6C6 and 10D5 to βAP, whereas it inhibits weakly the interaction of 2H3 with βAP. Low affinity binding of mAb 2H3 to …

We have developed an immunization procedure for the production of effective anti-beta-amyloid (anti-Abeta) antibodies, using filamentous phage displaying only 4 amino acids. The EFRH …