2024年12月24日 · EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) is a Protein Coding gene. Diseases associated with EGLN3 include Pheochromocytoma and Renal Cell Carcinoma. Among its related pathways are Cellular responses to stimuli and Autodegradation of …

Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene. [5] ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.

Enables peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Located in cytosol and nucleus. Implicated in renal cell carcinoma.

2024年1月4日 · egln3是一种重要的蛋白，通过氧传感途径调节细胞对缺氧的反应。它抑制hif-1α的表达，影响多种生理和病理过程。基于对egln3的深入了解，研究人员已开发出针对egln3的抑制剂和激活剂，并发现egln3的表达水平可作为某些疾病的生物标志物。

2025年2月8日 · EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-kappaB signalling activation independent of hydroxylase activity. E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression. PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma.

2022年6月15日 · EGLN3 has been shown to suppress EGFR activity through a hydroxylation-independent mechanism. EGLN3 physically interacts with EGFR, acting as a scaffold to promote binding with endocytic...

肿瘤组织往往存在不同程度的缺氧,对缺氧的适应性反应离不开缺氧诱导因子(hifs)的调控.脯氨酸羟化酶(eglns)属于亚铁依赖型双加氧酶,能够将hif-α亚基中特定的脯氨酸残基羟基化,从而控制参与肿瘤细胞增殖,分化,侵袭,迁移,凋亡以及血管生成等基因的转录.脯氨酸羟 ...

2024年1月4日 · EGLN3主要参与细胞中的氧传感途径，能够感知细胞内氧气浓度的变化，并通过调节HIF-1α (hypoxia-inducible factor 1 alpha)的降解，影响细胞对缺氧的反应。 EGLN3的功能的关联：

EGLN3 inactivation inhibits macrophage migration, efferocytosis, and M2 polarization. Studies using EGLN3 catalytically inactive knock-in mice indicate that inactivation of EGLN3 hydroxylase in host cells ameliorates LLC cancer growth through reprogramming the …

Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse. Enables peptidyl-proline dioxygenase activity. Involved in regulation of cell population proliferation and regulation of neuron apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor.