2024年12月24日 · EIF2AK4 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4) is a Protein Coding gene. Diseases associated with EIF2AK4 include Pulmonary Venoocclusive …

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene. [ 5 ] [ 6 ] EIF2AK4 belongs to a family of kinases that phosphorylate the …

该基因编码激酶家族的成员，磷酸化真核翻译起始因子 2 (EIF2) 的 α 亚基，导致蛋白质合成下调。 编码的蛋白质通过结合不带电的转移 RNA 来响应氨基酸剥夺。 它也可能被葡萄糖剥夺和病毒 …

2013年12月1日 · Using whole-exome sequencing, we detected recessive mutations in EIF2AK4 (also called GCN2) that cosegregated with PVOD in all 13 families studied. We also found …

Using whole-exome sequencing, we detected recessive mutations in EIF2AK4 (also called GCN2) that cosegregated with PVOD in all 13 families studied. We also found biallelic EIF2AK4 …

Mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene have recently been identified in recessively inherited veno-occlusive disease. In this study we assessed if …

2025年1月4日 · describe the recessive, loss-of-function mutation atchoum (atc) in Eif2ak4, encoding GCN2, which increased susceptibility to infection by the double-stranded DNA …

2016年5月3日 · EIF2AK4 depletion inhibited autophagy activation in response to LF82 infection, leading to increased LF82 intracellular replication and elevated pro-inflammatory cytokine …

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; 603907) to downregulate protein synthesis in response …

2024年10月5日 · EIF2AK4基因（编码GCN2）的隐性突变及其导致的GCN2蛋白表达减少与遗传性肺静脉阻塞病（PVOD）相关，这是一种罕见的严重肺动脉高压（PAH）亚型，特征为隔膜静 …