2025年2月11日 · In this study, we investigated the in vivo function of eIF3a using eIF3a knockout and knockdown mouse models and found that eIF3a deficiency resulted in splenic tissue structural disruption and multi-organ damage, which contributed to severe sepsis induced by Lipopolysaccharide (LPS).

2024年12月24日 · EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Craniotubular Dysplasia, Ikegawa Type and Breast Cancer. Among its related pathways are Peptide chain elongation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.

eIF3a是eIF3的最大亚基，它是翻译启动所有步骤的关键参与者。 上海懿贝瑞生物发现，eIF3a的主要功能表现在： 1）翻译启动。 作为翻译起始因子，eIF3a…

The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal ...

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. [5] [6] [7] It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

eIF3a (eukaryotic translation initiation factor 3a), a subunit of the eIF3 complex, has been suggested to play a regulatory role in protein synthesis and in cellular response to DNA-damaging treatments. S6K1 is an effector and a mediator of mTOR complex 1 (mTORC1) in regulating protein synthesis and …

2018年1月1日 · eIF3a is the largest subunit of eIF3, which is a key player in all steps of translation initiation. During the past years, eIF3a is recognized as a proto-oncogene, which is an important discovery in this field. It is widely reported to be correlated with cancer occurrence, metastasis, prognosis, and …

2018年1月1日 · eIF3a is the largest subunit of eIF3, which is a key player in all steps of translation initiation. During the past years, eIF3a is recognized as a proto-oncogene, which is an important discovery in this field. Recently, it is emerging as a new potential drug target in the eIF family and some small molecule inhibitors are developed.

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content. Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.

2021年12月9日 · Here, we report that eIF3a undergoes dynamic O -linked N -acetylglucosamine (O -GlcNAc) modification in response to nutrient starvation. Stress-induced de- O -GlcNAcylation promotes eIF3...