2024年12月24日 · EIF6 (Eukaryotic Translation Initiation Factor 6) is a Protein Coding gene. Diseases associated with EIF6 include Epilepsy, Idiopathic Generalized 4 and Shwachman-Diamond Syndrome 1. Among its related pathways are Translational Control and Genetic causes of porto-sinusoidal vascular disease.

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene. [5] Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton.

2022年3月23日 · We set out to further validate the hypothesis that eIF6 dynamically rebinds to post-termination cytoplasmic 60S ribosomal subunits by engineering a transgenic eIF6 mouse strain that permits ...

2021年8月12日 · Reduction of eIF6 levels protects the liver from disease progression. eIF6 depletion blunts lipid accumulation, increases fatty acid oxidation (FAO) and reduces oncogenic transformation in...

Studies indicate that eukaryotic translation initiation factor 6 (eIF6) is a central regulator of metabolism independent from mTOR protein and myc proto-oncogene protein (Myc). Propose that eIF6 is necessary for malignant pleural mesothelioma growth. EIF6 plays an important role in controlling cell motility and tumor metastasis.

2015年9月18日 · Here we show that reduction of insulin-regulated translation in mice heterozygous for eIF6 results in normal glycaemia, but less blood cholesterol and triglycerides. eIF6 controls fatty acid...

真核翻译起始因子 6： 半桥粒是连接基底层和中间丝细胞骨架的结构。半桥粒的一个重要功能成分是整合素 beta-4 亚基 (ITGB4) ，这是一种含有两个 III 型纤连蛋白结构域的蛋白质。由该基因编码的蛋白质与 ITGB4 的纤连蛋白 III 型结构域结合，可能有助于将 ITGB4 连接到中间丝细胞骨架。所 …

2021年5月20日 · Although emerging studies indicate that eIF6 is aberrantly expressed in various types of cancers, the functions and underlying molecular mechanisms of eIF6 in the pathological progression of hepatocellular carcinoma (HCC) remain unclear. This study aimed to evaluate the potential diagnostic and prognostic value of eIF6 in patients with HCC.

2016年12月2日 · 真核起始因子 6 (eIF6) 是 60S 核糖体成熟所必需的因子。 eIF6 还充当细胞质翻译起始因子，位于生长因子刺激的下游。 eIF6 在几种肿瘤类型中上调。 小鼠模型的数据表明，eIF6 细胞质活性是 Myc 诱导的淋巴瘤发生的限速。 尽管如此，eIF6 既不受 Myc 的转录调控，也不受 mTOR 的转录后调控。 eIF6 刺激肿瘤生长所需的糖酵解和脂肪酸合成程序。 eIF6 增加脂肪生成所需的转录因子的翻译，如 CEBP/β、ATF4 和 CEBP/δ。 胰岛素刺激导致 eIF6 缺 …

2024年12月27日 · Introduction. Assembly of ribosomal subunits is a complex process that spans the nucleolus to cytoplasm and requires several conserved trans-acting factors ().Eukaryotic translation initiation factor-6 (eIF6) is one such essential factor that is critical for 60S ribosomal subunit biogenesis and for moderating inter-subunit interactions (). eIF6 functions as an anti-association factor that ...