Ekram GAD | Cited by 1,128 | of University of Washington Seattle, Seattle (UW) | Read 78 publications | Contact Ekram GAD

We questioned whether overexpressed colorectal cancer associated proteins found at higher incidence and associated with poor prognosis could be effective vaccine antigens. We explored whether vaccines targeting these proteins could inhibit the development of intestinal tumors in the azoxymethane (AOM)-induced colon model and APC Min mice.

Vaccination against the Epidermal Growth Factor Receptor (EGFR) using a multipeptide vaccine in a preventive setting decreased EGFR-driven lung carcinogenesis by 76.4% in a mouse model of EGFR-driven lung cancer. We also demonstrate that anti-EGFR vaccination primes the development of a robust immune response in vivo.

2017年7月7日 · We evaluated HIF-1α-specific IgG in sera from controls and patients with breast cancer. Class II epitopes derived from the HIF-1α protein sequence were validated by ELISPOT. To assess therapeutic efficacy, we immunized Tg-MMTVneu and C3 (1)Tag mice with HIF-1α Th1-inducing peptides. Stem cells were isolated via magnetic bead separation.

2008年10月10日 · Insulin like growth factor binding protein-2 (IGFBP-2) has direct effects on breast cancer proliferation via stimulation of critical signaling pathways. We questioned whether IGFBP-2 was an immune target in breast cancer. IGFBP-2 specific IgG antibody immunity was preferentially detected in breast cancer patients as compared to controls (p=0.0008).

Ekram A Gad's 5 research works with 27 citations and 84 reads, including: COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating...

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Ekram Gad studies DNA methylation, Epigenetics, and Colorectal cancer.