2024年12月24日 · ELAVL1 (ELAV Like RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ELAVL1 include Ureteral Obstruction and Colorectal Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene. [5] [6] The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements in 3' untranslated regions.

2025年3月8日 · ELAVL1 regulates PD-L1 mRNA stability to disrupt the infiltration of CD4-positive T cells in prostate cancer. HuR promotes triglyceride synthesis and intestinal fat absorption. HuR controls glutaminase RNA metabolism. STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1beta-induced IL-8 production.

2025年2月1日 · Our study reveals that low expression of the RNA-binding protein ELAVL1 is linked to higher-grade malignancy and poorer prognosis in malignant BC subtypes. Notably, knockdown of ELAVL1 increased the expression of key stem cell markers (CD44, SOX2, OCT4, KLF4, and NANOG) and enhanced tumorsphere formation.

2024年6月17日 · 胚胎致死异常视觉蛋白1(embryonic lethal abnormal vision like 1,ELAVL1),又被称为人类抗原R(human antigen R,HuR),是一种典型的 RNA 结合蛋白(RNA binding protein,RBP),通过与 3'非翻译区(3'untranslated element,3'UTR)的AU富含元件(AU-rich element,ARE)结合,在mRNA转录和翻译过程中发挥重要作用.ELAVL1的 ...

2021年5月25日 · ELAVL1 transitions from binding overwhelmingly intronic sites to 3′ UTR sites upon immune stimulation of cells, binding previously and newly expressed mRNAs. We find that ELAVL1 mediates the RNA stability of genes that regulate pathways essential to pathogen sensing and cytokine production.

由该基因编码的蛋白质是 RNA 结合蛋白 ELAVL 家族的成员，该家族包含多个 RNA 识别基序，并选择性地结合在 mRNA 的 3' 非翻译区发现的富含 AU 的元件 (ARE) 。 AREs 发出 mRNA 降解信号作为调节基因表达的一种方式，因此通过结合 ARE，ELAVL 蛋白家族在稳定含有 ARE 的 mRNA 中发挥作用。 该基因与多种生物过程有关，并与包括癌症在内的多种疾病有关。 它在许多癌症中高度表达，并可能在癌症诊断、预后和治疗中发挥潜在作用。 [RefSeq 提供，2012 年 …

2021年5月25日 · We find that ELAVL1 mediates the RNA stability of genes that regulate pathways essential to pathogen sensing and cytokine production. Our findings reveal the importance of examining RBP regulatory impact under dynamic transcriptomic events to understand their post-transcriptional regulatory roles within specific biological circuitries.

ELAVL1 is an m6A binding protein that can promote the occurrence and development of tumors in an m6A-dependent manner. In this study, we found that most m6A regulators were significantly dysregulated in PCa, and some m6A regulators were associated with …

2025年2月8日 · the RNA-binding protein ELAVL1 is essential for mouse spermatogenesis, the first genetic evidence of ELAVL1 involvement in spermatogenesis; HuR-driven posttranscriptional control plays a significant role in T cell development and effector function in both transgenic and human systems.