Finally, the DEF domain is specific for the interaction of activated extracellular signal-regulated kinase (Erk), a type of MAPK, with Elk1. [6] Given its role as a transcription factor, Elk1 is expressed in the nuclei of non-neuronal cells. The protein is present in the cytoplasm as well as in the nucleus of mature neurons. [6] .

2020年6月23日 · We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six...

2012年8月1日 · ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription.

ERK也会入核，磷酸化转录因子 Elk-1 (383位和389位的丝氨酸)。 通常只有一种高度活化的ERK1或ERK2存在于细胞内，相比非磷酸化的形式其活性高出1000倍。 在细胞中，随时都有三种活性较低的ERKs:一种没有磷酸化的，两种单磷酸化的 (酪氨酸位点或苏氨酸位点)。 JNK/SAPK (c-Jun kinase/stress activated protein kinase)级联反应 能被UV辐射、热激或者炎症因子激活。 如下图，举例其中一个途径： 这类MAPK通路可以由两种小G蛋白Rac和Cdc42介导。 活化 …

细胞外调节 蛋白激酶 (extracellular regulated protein kinases，ERK)包括ERK1和ERK2，是将信号从 表面受体 传导至细胞核的关键，其中ERK1和ERK2的分子量分别为44kDa和42kDa。 磷酸化激活的ERK1/2由胞质转位到核内，进而介导Elk-1，ATF，Ap-1，c-fos和c-Jun的转录活化，参与 细胞增殖 与分化、细胞形态维持、 细胞骨架 的构建、 细胞凋亡 和细胞的癌变等多种生物学反应。 ERK是80年代末期发现的一类丝/苏氨酸 蛋白激酶，是传递丝裂原信号的信号转导蛋白。 它正 …

星形细胞内富含的 PEA15（phosphoprotein enriched in astrocytes 15，磷酸蛋白 15）可与 ERK 紧密结合，并利用 ERK 的出核序列将其引导出核，因此通过过表达 PEA15 即能阻止 ERK 入核，降低 ERK 通路对细胞应答的调节活性。

2024年12月24日 · ELK1 (ETS Transcription Factor ELK1) is a Protein Coding gene. Diseases associated with ELK1 include Non-Syndromic X-Linked Intellectual Disability and Autism Spectrum Disorder. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

1995年3月1日 · We demonstrate that Elk-1, a protein closely related to p62TCF in function, is a nuclear target of two members of the MAP kinase family, ERK1 and ERK2. Phosphorylation of Elk-1 increases the yield of ternary complex in vitro. At least five residues in the C-terminal domain of Elk-1 are phosphorylated upon growth factor stimulation of NIH3T3 cells.

2011年3月15日 · When phosphorylated by the MAPK/ERK, Elk-1 translocates to the nucleus where it is implicated in regulating chromatin remodeling, SRE-dependent transcription, and neuronal differentiation. Another post-translational modification is the conjugation to SUMO (Small Ubiquitin-like MOdifier), which relocalizes Elk-1 in the cytoplasm.

Ets转录因子ELK1是Ets转录因子家族中三元复合物(ternary complex factor,TCF)亚家族成员之一,是MAPK/ERK信号通路的直接下游转录因子,磷酸化后具有激活ERK信号的功能.ELK1在干细胞 …