Elongation of very long chain fatty acids protein 4 is a protein that in humans is encoded by the ELOVL4 gene. [5] [6]ELOVL4 is a member of a large family of fatty acid elongases (ELO) that catalyzes the rate-limiting step in the elongation of long chain fatty acids (LC-FA) into very long-chain saturated (VLC-SFA) and polyunsaturated (VLC-PUFA) fatty acids, collectively known as VLC-FA (very ...

2024年12月24日 · ELOVL4 (ELOVL Fatty Acid Elongase 4) is a Protein Coding gene. Diseases associated with ELOVL4 include Spinocerebellar Ataxia 34 and Stargardt Disease 3. Among its related pathways are Fatty acyl-CoA biosynthesis and Metabolism.

2023年11月20日 · The very-long-chain fatty acid elongase (ELOVL) family plays essential roles in lipid metabolism and cellular functions. This comprehensive review explores the structural characteristics, functional properties, and physiological significance of individual ELOVL isoforms, providing insights into lipid biosynthesis, cell membrane dynamics, and ...

2025年3月1日 · Elongation occurs in the endoplasmic reticulum (ER) through the actions of a complex of four ER-embedded enzymes, which includes the ELOVL proteins. Together with desaturases that introduce double bonds, these processes significantly increase the …

The ELOVL4 gene provides instructions for making a protein that is found primarily in the retina, the specialized light-sensitive tissue that lines the back of the eye. Specifically, the ELOVL4 protein is produced in the retina's light-sensing cells (photoreceptors).

elovl 脂肪酸延长酶 4： 该基因编码一种膜结合蛋白，它是 elo 家族的一员，参与脂肪酸生物合成的蛋白质。 与视网膜感光细胞中编码蛋白的表达一致，该基因的突变和小缺失与 Stargardt 样黄斑营养不良 (STGD3) 和常染色体显性 Stargardt 样黄斑营养不良 (ADMD) 有关，也 ...

The ELOVL4 gene encodes the protein “elongation of very long chain fatty acids-4,” a biosynthetic enzyme in the endoplasmic reticulum responsible for the synthesis of fatty acids with more than 26 carbons.

2019年9月20日 · ELOVL4 is the only family member that catalyzes production of Very Long Chain Saturated Fatty Acids (VLC-SFA) and Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFA) with chain lengths ≥28 carbons.

2019年3月1日 · ELOngation of Very Long chain fatty acids-4 (ELOVL4) is an elongase responsible for the biosynthesis of very long chain (VLC, ≥C28) saturated (VLC-SFA) and polyunsaturated (VLC-PUFA) fatty acids in brain, retina, skin, Meibomian glands, and testes. Fascinatingly, different mutations in this gene have been reported to cause vastly different ...

ELOVL4 is identified as the causative gene for erythrokeratodermia variabilis and spinocerebellar ataxia in a French-Canadian family. A novel homozygous nonsense mutation in ELOVL4 cuases a neuro-ichthyotic disorder with variable expressivity.