2024年12月24日 · ELOVL5 (ELOVL Fatty Acid Elongase 5) is a Protein Coding gene. Diseases associated with ELOVL5 include Spinocerebellar Ataxia 38 and Spinocerebellar Ataxia 13. Among its related pathways are docosahexaenoate biosynthesis IV (4-desaturase, mammals) and Epigenetic regulation by WDR5-containing histone modifying complexes.

elovl5 是一种长链脂肪酸延长酶，主要负责将18个碳脂肪酸延伸到20个碳。elovl5将γ-la转化为dihomo-γ-la（dgla， 20：3）。最后，fads1将dgla去饱和为aa。因此，fads1、fads2和elovl5已被确定为铁死亡的增强子。 游离脂肪酸（ffa）要酯化成pl，必须首先与辅酶a（coa）结合。

Elongation of very long chain fatty acids protein 5 is a protein that in humans is encoded by the ELOVL5 gene. [5] [6]

2025年2月8日 · ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer. The that maternal genetic variants in ELOVL2 and ELOVL5 were associated with PUFA levels in breast milk and that the combination of SNP haplotypes and …

elovl5 是 不饱和脂肪pufa 相关过程中的关键酶，在肝脏甘油三酯代谢中起着关键作用。 该研究发现，小鼠全身性 elovl5 缺乏会导致明显的肝脏异常，例如肝肿大、脂肪变性、肝细胞气球样变性、炎症和纤维化，尽管全身代谢改变有限。

It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38).

2021年4月1日 · Potent and direct AR-mediated induction of ELOVL fatty acid elongase 5 (ELOVL5), an enzyme that catalyzes fatty acid elongation, was demonstrated in prostate cancer cells, xenografts, and clinical tumors.

2024年2月4日 · Title: ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer. The that maternal genetic variants in ELOVL2 and ELOVL5 were associated with PUFA levels in breast milk and that the combination of SNP haplotypes and higher DHA intake increased PUFA concentrations.

2021年4月1日 · 在前列腺癌细胞、异种移植物和临床肿瘤中证明了有效和直接的 ar 介导的 elovl 脂肪酸延长酶 5 (elovl5) 是一种催化脂肪酸延长的酶。 对大规模数据集中 mRNA 和蛋白质的评估显示，与非恶性前列腺相比，ELOVL5 是前列腺癌中表达和上调的主要 ELOVL。

Elongation of very long-chain fatty acid (ELOVL) family enzymes catalyze fatty acid elongation, and ELOVL5 is indispensable for PUFAs elongation, but its role in RCC progression remains unclear. Here, we show that higher levels of ELOVL5 correlate with poor RCC clinical prognosis.