2024年9月27日 · EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice. Activated SIRT3 initiates …

The aim of this study was to determine whether empagliflozin (EMPA) improves obesity-related cardiac dysfunction via regulating Sestrin2-mediated pathways in diet-induced obesity. …

新型降糖药物钠– 葡萄糖协同转运蛋白-2 (sodium-glucose cotrans-porter 2, SGLT2)抑制剂除了能够降低容量负荷、减少心血管死亡及住院风险外,还展现出改善心脏结构和功能、逆转心脏重 …

2023年12月11日 · EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice and provides a new explanation …

2023年1月11日 · EMPA significantly reversed cardiac dysfunction on echocardiography in diabetic mice and inhibited excessive autophagy in high-glucose-treated cardiomyocytes by …

2024年7月23日 · Our findings revealed that EMPA mitigates cardiac inflammation and aging in HFpEF mice by inhibiting STAT1 activation. The STAT1–STING axis may act as a pivotal …

2022年5月9日 · EMPA significantly increased the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream genetic targets in cardiac tissue of type 2 diabetic db/db …

2025年2月1日 · SIRT3 protects against myocardial hypertrophy, heart failure, cardiac insufficiency. SRT3 impact neurodegenerative diseases by providing sufficient ATP to the …

2024年9月27日 · EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice. Activated SIRT3 initiates …

2024年1月1日 · SIRT3 promotes glucose transport to cardiomyocytes by activating glucose transporter types 1 (GLUT1) and 4 (GLUT4). SIRT3 can also regulate phosphofructokinase …