2024年9月27日 · EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice. Activated SIRT3 initiates autophagy through AMPK/Beclin1 and further stimulates elongation of …

The aim of this study was to determine whether empagliflozin (EMPA) improves obesity-related cardiac dysfunction via regulating Sestrin2-mediated pathways in diet-induced obesity. C57BL/6J mice and Sestrin2 knockout mice were fed a high-fat diet (HFD) for 12 weeks and then treated with or without EMPA (10 mg/kg) for 8 weeks.

新型降糖药物钠– 葡萄糖协同转运蛋白-2 (sodium-glucose cotrans-porter 2, SGLT2)抑制剂除了能够降低容量负荷、减少心血管死亡及住院风险外,还展现出改善心脏结构和功能、逆转心脏重构的潜力。 本文旨在对SGLT2 抑制剂在改善心脏重塑方面的研究进展进行综述。 *通讯作者。 文章引用: 宋琦, 凌智瑜. 钠- 葡萄糖共转运蛋白2 抑制剂改善病理性心脏重塑的研究进展[J]. 临床医学进展, 2024, 14(8): 429-438. DOI: 10.12677/acm.2024.1482233. modeling serves as an independent …

2023年12月11日 · EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice and provides a new explanation for the cardioprotective benefits of EMPA in obesity.

2023年1月11日 · EMPA significantly reversed cardiac dysfunction on echocardiography in diabetic mice and inhibited excessive autophagy in high-glucose-treated cardiomyocytes by inhibiting the autophagy inducer glycogen synthase kinase 3 beta (GSK3β), leading to reactivation of cardiomyogenic transcription factors.

2024年7月23日 · Our findings revealed that EMPA mitigates cardiac inflammation and aging in HFpEF mice by inhibiting STAT1 activation. The STAT1–STING axis may act as a pivotal mechanism in the pathogenesis of HFpEF, especially under inflammatory and aging conditions.

2022年5月9日 · EMPA significantly increased the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream genetic targets in cardiac tissue of type 2 diabetic db/db mice and H9C2 cells. EMPA also downregulated the expression of mitochondrial fission-related proteins and upregulated the expression of mitochondrial fusion-related proteins.

2025年2月1日 · SIRT3 protects against myocardial hypertrophy, heart failure, cardiac insufficiency. SRT3 impact neurodegenerative diseases by providing sufficient ATP to the brain. Sirtuin-3 (SIRT3) in mitochondria has nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase activity.

2024年9月27日 · EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice. Activated SIRT3 initiates autophagy through AMPK/Beclin1 and further stimulates elongation of …

2024年1月1日 · SIRT3 promotes glucose transport to cardiomyocytes by activating glucose transporter types 1 (GLUT1) and 4 (GLUT4). SIRT3 can also regulate phosphofructokinase (PFK) activity, significantly reduce the expression of TP53-induced glycolysis and apoptosis regulator (TIGAR), and enhance glucose metabolism [32], [42]. SIRT3 can also target the ...