The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +). It is …

2013年8月20日 · CHANNEL (ENaC) inhibitor amiloride has been used as an antihypertensive for many years. While it is thought to be a mild diuretic, it is used as an antihypertensive in …

Epithelial sodium channels (ENaC) are processed by proteases as they transit the biosynthetic pathway. We recently observed that furin-dependent processing of the alpha-subunit of ENaC …

该药物是第一种不含阿米洛利结构基团的ENaC抑制剂，适合通过Respimat® Soft Mist™吸入器吸入，并且具有长效作用。 论文还介绍了BI 1265162的合成方法，并且该方法可用于支持临床 …

2018年12月14日 · complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and ENaC degradation. Functional 1Pix is required for ENaC inhi-bition by AMPK and promotes Nedd4-2 …

2012年1月18日 · Amiloride analogs induce natriuresis by inhibiting the epithelial Na channel (ENaC), which localizes to the apical regions of principal cells (17). Since ENaC does not trans …

To identify sites involved in Cl inhibition, we mutated residues in the extracellular domain of -, -, and ENaC that are homologous to the Cl binding site in acid-sensing ion channel 1a and …

ENaC和ASIC分子（ENaC超家族）在特定的背部感觉神经元束、三叉神经和传入神经中均有分布，并通过这些神经达到支配躯体和内脏感受器的效果24,25。Heather26

2023年7月24日 · The ENaC causes endothelium-dependent relaxation impairment in mice aorta through the ROS/COX-2-mediated SGK-1/Nedd4-2 signaling pathway; blocking the ENaC …