The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +). It is …

The ENaC causes endothelium-dependent relaxation impairment in mice aorta through the ROS/COX-2-mediated SGK-1/Nedd4-2 signaling pathway; blocking the ENaC facilitates …

2022年3月21日 · In this review, we focus on a subclass of membrane‐bound and soluble proteases that are defined as channel‐activating proteases (CAPs), since they induce Na + ion …

2018年1月1日 · ENaC is a constitutively active channel and allows the Na + transport from the extracellular fluid into the cytoplasm (Hanukoglu and Hanukoglu 2016). In the epithelial cells of …

Increased ENaC expression could cause stiffening in endothelia resulting in reduced availability of nitric oxide—a characteristic early sign of HTN . ENaC is an important regulator of vascular …

2021年6月1日 · The Epithelial Na + Channel, ENaC, comprised of 3 subunits (αβγ, or sometimes δβγENaC), plays a critical role in regulating salt and fluid homeostasis in the body. It regulates …

上皮钠离子通道（enac），又叫阿米洛利敏感钠离子通道 （aasc），是控制钠离子通过细胞膜的跨膜离子通道。 ENaCs主要位于肾脏、汗腺、肺以及结肠，功能是重吸收钠离子帮助维持盐 …

上皮 Na+ 通道 ENaC 由 3 个亚基（αβγ，或有时 δβγENaC）组成，在调节体内盐和液体的稳态中起关键作用。 它调节从肾脏到血流中的液体重吸收以控制血容量和压力，调节肺中的液体吸 …

Active transepithelial sodium (Na +) transport by alveolar epithelial cells (AEC) is a driving force for reabsorption of fluid from the alveolar space, a function which accounts for the ability of the …

The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic factors that …