The endoplasmic reticulum (ER) is a part of a transportation system of the eukaryotic cell, and has many other important functions such as protein folding. The word endoplasmic means "within the cytoplasm", and reticulum is Latin for "little net".

2024年12月21日 · The endoplasmic reticulum or ER is a network of membranes extending from the nuclear envelope that acts as the factory and highway of the cell. It exists in two types: rough ER (protein synthesis) and smooth ER (lipid synthesis and detoxification). The ER works closely with the Golgi apparatus but has distinct roles.

2025年3月21日 · The endoplasmic reticulum (ER) is a continuous membrane system that forms a series of flattened sacs within the cytoplasm of eukaryotic cells. All eukaryotic cells contain an ER. In animal cells, the ER usually constitutes more than half of the membranous content of the cell.

2023年9月15日 · Accumulation of misfolded and unfolded protein in endoplasmic reticulum (ER) will replace the BiP binding on PERK, ATF6 and IRE1, and activate them. PERK causes the phosphorylation of eIF2α,...

The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct domains; consisting of tubules, sheets and the nuclear envelope.

2021年1月15日 · The endoplasmic reticulum (ER) is a large organelle made of membranous sheets and tubules that begin near the nucleus and extend across the cell. The endoplasmic reticulum creates, packages, and secretes many of the products created by a cell. Ribosomes, which create proteins, line a portion of the endoplasmic reticulum.

2023年4月1日 · Within the cytoplasm of most animal cells is an extensive network (reticulum) of membrane-limited channels, collectively called the endoplasmic reticulum (or ER). The endoplasmic reticulum is a name derived from the fact that in the light microscope it looks like a “net in the cytoplasm.”

Among many cell organelles present in the cell, the endoplasmic reticulum (ER) is the largest membrane-bound organelle of the eukaryotes, but the prokaryotes lack these organelles.

Here, we review the current understanding of how ER regulates endo-lysosomal pathways, the molecular composition and cellular function of ER-endo/lysosomal MCSs, and how changes in ER structure can compromise this interaction and contribute to disease states.

The ER Is the Point of Entry into the Endomembrane System for Newly Synthesized Proteins. The ER consists of flattened membrane sacs, known as cisternae, and tubules. It is directly connected to the outer membrane of the nuclear envelope, but unlike most of the cartoons of the ER found in textbooks like this, it stretches throughout the entire ...