2014年12月8日 · When exo and endo isomers can form in the Diels-Alder reaction, there is often a preference for formation of the endo isomer. Although this endo preference is often referred …

Diels-Alder's "endo rule" was born from experiment, and is also not actually a rigid "rule" (see tuning endo/exo selectivity in the two papers, and in the stack exchange related question by …

2014年6月7日 · However, the Diels–Alder is a reversible reaction. In this case, the exo product is thermodynamically favored over the endo product by about $\pu{1.9 kcal/mol}$. So, even …

2019年2月23日 · Now, on topic: my impression is generally that exo > endo selectivity is more of a factor for small ring sizes. 5-endo reactions are not allowed, for example, but 6-endo can …

2015年7月7日 · How do the 1,3-dipolar cycloadditions follow the endo rule as in the reaction below, where the anti diastereoisomer is formed predominantly?

2015年10月13日 · 2) We would predict that the product is the endo- product, which would have the bridging ester on the opposite side of the cyclohexene relative to the methyl ketone. This …

2022年1月7日 · To obtain the racemic endo product, flip the diene 180 o in conformation 1 to obtain endo 2. For the enantiomer, flip the unsaturated aldehyde 180 o. If you have access to …

2018年12月30日 · I'm familiar with the endo rule as well as the regioselectivity of the reaction. However, what I fail to understand is the stereoselectivity of the product in relation to the …

The 5-endo-trig acetal formation is actually one of the most well known exceptions to Baldwin's rules (Baldwin himself acknowledged this). In an 1981 JOC paper ( J. Org. Chem. 1981 , 46 , …

2017年10月10日 · I have basic understanding of the Endo Rule (endo product favored over exo product), but have trouble with the stereo chemistry involved. I also know that the symmetry of …