2023年3月28日 · AD-related endothelial transcriptomic changes also increased along the Braak stage continuum but showed limited overlap with region-specific genes. Analysis of how endothelial cell genes associate with AD pathological burden revealed six overall trends suggestive of distinct temporal relationships with AD disease progression.

2020年10月22日 · Endothelial cells tend to get short shrift in studies of Alzheimer’s, but new results now implicate these cells in the toxic brain environment of people with this disease. In the September 28 Proceedings of the National Academy of Sciences, researchers led by Nancy Ip at the Hong Kong University of Science and Technology analyzed a large ...

2020年6月15日 · The full complexity of the blood-brain barrier, with its different cell types acting together, has been difficult to model in vitro. In the June 8 Nature Medicine, researchers led by Li-Huei Tsai at the Massachusetts Institute of Technology, Cambridge, debuted a model that combined endothelial cells, astrocytes, and pericyte-like cells in a ...

2023年6月22日 · Capillary endothelial cells, the majority of endothelial cells (ECs) in the brain, showed the highest number of differentially expressed genes (DEGs) in AD, which included cell junction and adhesion-associated genes as well as genes involved in BBB transport. DEGs in arterial ECs included tight junction components.

2021年5月9日 · Betsholtz reported a gradual shift in the expression profile of endothelial cells along the arteriovenous continuum, i.e., the progression of the vasculature from arteries to capillaries to veins. By contrast, the delineations between different smooth muscle cell (SMC) and pericyte populations were sharp (Vanlandewijck et al., 2018).

2022年6月23日 · In the June 14 Cell Reports, they reported that these animals had mostly diffuse, not dense-core, plaques and that these accumulated in and around the tiny blood vessels of the brain. Without microglia, endothelial integrity faltered, calcium crystals accumulated in the thalamus, and the blood vessels burst. Most animals died by 6 months old.

2021年10月28日 · In vitro, the viral protease cleaved NF-κB essential modulator. NEMO, a transcription factor, triggers host antiviral responses and prevents endothelial cell death. Without NEMO, endothelial cells perished by necroptosis. In NEMO knockout mice, inhibiting the necroptotic kinase RIPK3 preserved brain blood vessels and BBB integrity. Though ...

2019年11月15日 · Axel Montagne University of Edinburgh; Posted: 15 Nov 2019 This is a noteworthy study by the Daneman lab comparing the transcriptional profiles of mouse blood-brain barrier (BBB) endothelial cells (ECs) with those in other organs of the body (i.e., heart, lung, kidney, and liver) using RNA-Seq method and an inducible endothelial-specific reporter mouse …

Neflamapimod inhibits endothelial cell activation, adhesion molecule expression, leukocyte attachment and vascular inflammation by inhibiting p38 MAPKα and NF-κB signaling. Biochem Pharmacol. 2023 Aug;214:115683. Epub 2023 Jul 8 PubMed. External Citations. press release; slides posted; company press release; EU Clinical Trials Register

Toward this goal, the authors tested Aβ for effects on human brain microvascular endothelial cell (HBMVEC) monolayers. They found that an unpurified mixture of Aβ comprising monomers, oligomers, and fibrils made THP-1 monocytes more adhesive to the monolayers by twofold, and that twice as many THP-1 cells migrated through the monolayers.