Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is:

Enolase is located mainly in the cytosol of all eukaryotic cells where, besides its function in glycolysis and gluconeogenesis, it is also involved in regulation of cell morphology and material trafficking by interacting with the cytoskeleton system [18].

Enolase is a glycolytic metalloenzyme involved in carbon metabolism. The advantage of targeting enolase lies in its essentiality in many biological processes such as cell wall formation, RNA turnover and as a plasminogen receptor. We initially used a DARTS assay to identify enolase as a target in Escherichia coli.

Enolase, a glycolytic enzyme that catalyzes the dehydration of 2-phospho- d -glycerate (PGA) to form phosphoenolpyruvate (PEP), is a homodimer in all eukaryotes and many prokaryotes. Here, we report the crystal structure of a complex between yeast …

烯醇化酶 （英語： Enolase，又被称为 磷酸烯醇式丙酮酸水合酶， phosphopyruvate hydratase）是负责催化 糖酵解 的第九步反应， 2-磷酸甘油酸 （2-PG）转化为 磷酸烯醇式丙酮酸 （PEP）的 金属酶。

The crystal structure of the human neuronal enolase-Mg2F2P i complex (enolase fluoride/phosphate inhibitory complex, EFPIC) determined at 1.36 Å resolution shows that the combination of anions effectively mimics an intermediate state in catalysis.

Here, the crystal structure of human ENO1 (hENO1) is presented at 2.2 A resolution. Despite its high sequence similarity to other enolases, the hENO1 structure exhibits distinct surface properties, explaining its various activities, including plasmin (ogen) and DNA binding.

2001年10月26日 · Enolase is a glycolytic enzyme that catalyzes the dehydration of 2-phospho- d -glycerate (G2P) to phosphoenolpyruvate and the reverse reaction in gluconeogenesis. A highly conserved protein at the level of sequence, enolase may also have a …

Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme.

1996年12月1日 · Structure of enolase Type I enolase from yeast has 436 amino acids per subunit. In yeast and most higher organisms enolase subunits assemble into dimers. The primary structure of enolase is highly conserved. Each subunit consists of an …