Env is a viral gene that encodes the protein forming the viral envelope. [1] The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane .

Env（包膜糖蛋白基因）是病毒的一个基因，其编码的病毒蛋白用于形成病毒包膜 [1] 。 逆转录病毒 的 env 基因表达使得其能特异性地吸附在靶细胞的表面，并穿过 细胞膜 进入细胞 [ 2 ] 。

The env gene product or “spike protein” is a glycoprotein located on the virion surface that plays an essential role in viral transmission by firstly promoting attachment to cellular surfaces through the recognition of specific receptors.

The Human Immunodeficiency Virus type 1 (HIV-1) env gene encodes the only surface-expressed viral protein Env, a glycoprotein of 160 kD (gp160), which is solely required for binding and entry into host cells.

The env gene encodes a glycosylated polyprotein of about 160 kDa (gp160) that is subsequently cleaved by a host cell protease to generate the viral envelope proteins gp120 and gp41. These two chains associate non-covalently in trimers to form the viral envelope spikes extending from the virion envelope.

The env gene is of particular significance because it serves as a target of host immune system response during the development of conventional vaccines against viruses. The env gene product, Env, is cleaved into two components – the trimeric, surface gp120 protein and TM gp41.

As discussed in Chapter 2, it is the product of the retroviral env gene that allows retroviruses to attach to target cells and penetrate the cell membrane. All env genes occupy a common genomic location downstream from the gag and pol genes, they are expressed via spliced mRNAs, and they have an organization similar to that of precursor ...

Among HIV-1 proteins, the envelope glycoprotein complex (Env) has been concentrated on in many studies for its important role in the immune response and in the first steps of viral replication.

In this chapter, we focus on advances in our knowledge of the Env structure and function as related to its interaction with CD4, coreceptors, and neutralizing antibodies emphasizing conservation of Env structural elements that could be used …

2024年8月15日 · Escape virus contained mutations in the env gene that were unexpectedly sparse, did not map generally to known neutralization epitopes, and involved primarily changes in N-linked glycosylation. The mechanisms by which HIV infection affects the induction of CD40L expression appear to involve HIV gp120-mediated engagement of CD4 and are key to ...