2024年11月1日 · To explore causality, we analyze scRNAseq data of mouse LLC1 tumors treated with EP2 and EP4 antagonists and discover that inhibition of PGE 2-EP2/EP4 reverses the …

Anti-inflammatory, anti-thrombotic and vasoprotective effects have been proposed for the EP4 receptor, along with its recently described unfavorable tumor-promoting and pro-angiogenic …

This review summarizes PGE 2 /EP4 signal inhibition in relation to the cancer-immunity cycle (C-IC), which describes fundamental tumor-immune interactions in cancer immunotherapy. PGE …

2020年5月29日 · In addition to tumor cell-autonomous roles of EP4, many EP4-positive host cells play a role in tumor behavior. Endothelial cell-EP4 supports tumor angiogenesis and …

2020年3月9日 · In animal studies, selective inhibition of the prostaglandin E receptor 4 (EP4), one of four PGE 2 receptors, suppresses tumor growth, restoring the tumor immune response …

In this study, using the immune checkpoint inhibitor-insensitive mouse cancer model and single-cell RNA sequencing, we show that PGE 2 -EP2/EP4 signaling simultaneously promotes …

2020年3月10日 · EP4 antagonist therapy is suggested to inhibit the immune-suppressive and tumorigenic roles of PGE 2 in tumors, and it may sensitize the therapeutic effects of ICIs in …

EP4 overexpression has a number of potential effects that may enhance the development and spread of malignancy. PGE2 induces migration of tumor cells in vitro and endogenous EP4 …

Here we used the highly metastatic syngeneic murine C3L5 breast cancer model to test the role of EP4-expressing macrophages in vascular endothelial growth factor (VEGF)-C/D production, …

2018年3月29日 · These cellular events are stimulated in COX-2 expressing breast tumors by activation of EP4 on tumor cells and tumor-associated host cells (immune cells, endothelial …