2011年4月24日 · Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved...

Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved inhibitors broadly impaired infection by all major HCV genotypes and viral escape variants in cell culture and in a human liver chimeric mouse model in vivo.

2024年12月25日 · ( EPHA2_HUMAN,P29317) (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

HCV is an enveloped, positive-stranded RNA virus belonging to the Hepacivirus in the Flaviviridae family. The HCV virion is comprised of a nucleocapsid surrounded by a host-derived membrane containing the E1 and E2 HCV glycoproteins [17].

2011年7月4日 · Epidermal growth factor receptor (EGFR) and ephrin receptor A2 (EphA2) have a key role in HCV entry, and inhibition of these host receptor tyrosine kinases (RTKs) could provide a viable new...

By inhibiting EGFR and EphA2 with existing PKIs, the researchers showed that HCV infection by all major HCV genotypes and viral escape mutants was impaired both in cell culture and in an in...

Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved...

By targeting conserved host proteins involved in the HCV life cycle, host-targeting agents (HTAs) offer opportunities for pan-genotypic antiviral approaches with a high barrier to drug resistance.

Using a functional RNAi kinase screen we identified epidermal growth factor receptor and ephrin receptor A2 as host co-factors for HCV entry. Blocking of kinase function by approved inhibitors broadly inhibited HCV infection of all major HCV genotypes and viral escape variants in cell culture and an animal model in vivo.

2020年10月13日 · 为了测试HCV进入过程中SRFBP1的重新定位，作者将Huh-7.5细胞暴露于HCV E2糖蛋白（eE2）的纯化胞外域。 这导致SRFBP1和CD81的共定位增加（皮尔逊相关系数0.5），当共同施用E2阻断抗体时可以逆转（图5）。 值得注意的是，在eE2暴露后和HCV暴露后的肝癌细胞中观察到SRFBP1募集到CD81阳性隔室中。 总而言之，数据表明 SRFBP1部分位于人肝癌细胞的细胞内膜上，并且HCV糖蛋白暴露促进SRFBP1和CD81的共定位。 此外，作者还测 …