Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins) are a family of proteins that serve as the ligands of the Eph receptor. Eph receptors in turn compose the …

Ephrins 可分为两大类，一种是通过 糖基磷脂酰肌醇 (GPI) 部分连接到细胞膜上的 ephrinAs (A1-A6)，另一种是跨越细胞膜并拥有细胞质信号域的 ephrinBs (B1-B3)。 在人类基因组中，共 …

2023年11月23日 · 我提供了关于Eph受体-ephrin介导的细胞间通讯和细胞自主信号传导的不同机制的最新信息，以及Eph系统与其他信号系统的相互作用。 进一步讨论了最近在阐明Eph系统如 …

摘要: 促红细胞生成素肝细胞激酶 (Erythropoietin-producing hepatocellular, Eph)受体家族作为目前已知最大的酪氨酸激酶受体家族，通过受体–配体结合，介导人类从胚胎发育到成人组织稳态 …

Ephrins 可分为两大类，一种是通过糖基磷脂酰肌醇 (GPI) 部分连接到细胞膜上的ephrinAs (A1-A6)，另一种是跨越细胞膜并拥有细胞质信号域的ephrinBs (B1-B3)。 Ephrins 及 Eph 受体均 …

2002年7月1日 · Biological functions for Eph receptors and ephrins include vascular development, tissue-border formation, cell migration, axon guidance and synaptic plasticity. Eph receptors …

2007年2月21日 · 双向信号传递是细胞间通讯领域中新近阐明的机制，酪氨酸激酶受体-配体 (Eph-ephrin) 介导的双向信号传递是此机制中的一个重要代表. Eph酪氨酸激酶家族受体及其配 …

2017年2月6日 · In this Primer we will discuss some of the key aspects of signalling by Ephs and ephrins that make them pivotal players in health and disease. Eph receptors were first …

2016年1月21日 · Ephrin–Eph signalling regulates cell migration in neurons, allowing the cells to reach their final destination, guides axons along intermediate choice points to reach their final …

EphrinA molecules, like many GPI-anchored proteins, are targeted to lipid rafts where they presumably assemble into protein complexes that transduce intracellular signals. Upon binding …

EphrinA/EphA-dependent axon repulsion is crucial for synaptic targeting in developing neurons but downstream molecular mechanisms remain obscure. Here, it is shown that …

Increased expression of EphA2 and EphrinA-1 plays an important role in the progression human gastric adenocarcinoma. The crystal structures of an A-class complex between EphA2 and …

Eph receptors and their ephrin ligands are important guidance molecules during neurological and vascular development. In recent years, it has become clear that the Eph protein family remains …

2019年7月3日 · Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue …

2010年11月11日 · Eph receptor tyrosine kinases and their ephrin ligands are critical regulators of cell contact-dependent signaling and patterning. Eph/ephrin binding can lead to very diverse …

2024年11月12日 · Ephrin binding induces the formation of different types of Eph receptor oligomers on the cell surface. An emerging concept is that large clusters of tyrosine …

EphB4 and EphrinB2 are the Eph/Ephrin molecules that play essential roles in vascular development and postnatal angiogenesis. Analysis of expression patterns and function has …

Conditioned media containing a soluble monomer of ephrinA1 caused EphA2 internalization and downregulation, dramatic alteration of cell morphology and suppression of the Ras–MAPK …

2002年2月1日 · Engagement of Eph receptors by ephrin ligands mediates critical steps of angiogenesis, including juxtacrine cell–cell contacts, cell adhesion to extracellular matrix, and …

Erythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is …