Epitope mapping - Wikipedia
By providing information on mechanism of action, epitope mapping is a critical component in therapeutic monoclonal antibody (mAb) development. Epitope mapping can reveal how a mAb exerts its functional effects - for instance, by blocking …
什么是Epitope表位？ - 知乎
抗原表位鉴定（ Epitope mapping ）的方法有许多，传统的抗原表位鉴定方法主要有合成多肽技术、肽扫描技术、丙氨酸突变技术、噬菌体展示技术、质谱技术、肽/蛋白微阵列技术等，但传统的表位鉴定方法大多基于功能性表位鉴定的方法，在一定程度上有其局限性 ...
An Introduction to Epitope Mapping - PubMed
The particular area of the antigen recognized by the antibody is called the epitope, and for proteinaceous antigens the epitope can be of complex nature. Information about the binding epitope of an antibody can provide important mechanistic insights and indicate for what applications an antibody might be useful.
表位作图 - 百度百科
对单克隆抗体和 多克隆抗体 识别蛋白质抗原表位的确定为免疫化学分析提供了十分有用的信息。 表位作图方法是检测免疫反应特异性和鉴定不同抗体的重要方法。它也被用来确定相关物质的特性，如蛋白修饰位点、蛋白片段的来源或该蛋白在细胞膜上的定位。
Epitope Mapping: The First Step in Developing Epitope-Based …
For epitope mapping, computational algorithms have been developed, such as Mapitope, which has recently been found to be effective in mapping conformational discontinuous epitopes. The pros and cons of various approaches towards epitope mapping are also discussed.
An Introduction to Epitope Mapping | SpringerLink
2018年5月1日 · The ability to identify epitopes has important applications for disease diagnosis, identification of vaccine candidates, or targets of autoantibodies. Epitope mapping is also central in the characterization of antibodies that bind therapeutic targets and has shown potential to stratify responders from non-responders for antibody-based therapy ...
Epitope Mapping - an overview | ScienceDirect Topics
Epitope mapping, or determination of the antigen-binding site to an antibody, is a useful tool in identifying B cell epitopes of a protein. This procedure necessitates having a panel of monoclonal or polyclonal antibodies available against the protein.
Antibody Binding Epitope Mapping (AbMap) of Hundred …
2021年1月1日 · AbMap enables, for the first time, linear epitope mapping of hundreds of antibodies simultaneously, at a much lower cost than that of traditional technologies, while maintaining high accuracy. The identified peptides/linear epitopes could be explored for a wide range of applications.
Epitope Mapping by Phage Display - PubMed
Knowing the epitope is valuable for the improvement of a biological product, e.g., a diagnostic assay, a therapeutic mAb, or a vaccine, as well as for the elucidation of immune responses. The current techniques for epitope mapping rely on the presentation of the target, or parts of it, in a way that it can interact with a certain mAb.
DECODE enables high-throughput mapping of antibody epitopes …
5 天之前 · Epitope analysis methods allow for a detailed understanding of antibody target specificity, but are often limited in their resolution and comprehensiveness. This study develops a high-throughput epitope analysis method called DECODE that provides single amino acid resolution for antibodies that recognize linear epitopes.