2024年12月25日 · EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15) is a Protein Coding gene. Diseases associated with EPS15 include Vaccinia and Menkes Disease. Among its related pathways are Signaling by EGFR and Uptake and actions of bacterial toxins.

2009年10月8日 · Eps15 has been shown to bind to AP-1 and AP-2 complexes, to bind to inositol lipids and to several other proteins involved in the regulation of intracellular trafficking. In addition, Eps15 has been detected in the nucleus of mammalian cells. Activation of growth factor receptors induces tyrosine phosphorylation and mono-ubiquitination of Eps15.

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene. [5] This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF.

Eps15 was originally identified as a substrate for the kinase activity of the epidermal growth factor receptor (EGFR). Eps15 has a tripartite structure comprising a NH2-terminal portion, which contains three EH domains, a central putative coiled-coil region, and a COOH-terminal domain containing mul …

Results indicate that phosphorylation of epidermal growth factor receptor pathway substrate 15 (Eps15) at Ser-796 is catalyzed by p38 directly. distinct forms of Eps15 direct EGFR to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S)

该基因编码的蛋白质是 EGFR 通路的一部分。 该蛋白质存在于网格蛋白包被的凹坑中，并参与受体介导的 EGF 内吞作用。 值得注意的是，该基因在急性髓性白血病中与 HRX/ALL/MLL 基因重排。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2009 年 5 月] This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF.

Antibodies specific for the eps15 gene product recognize two proteins: a major species of 142 kDa and a minor component of 155 kDa, both of which are phosphorylated on tyrosine following EGFR activation by EGF in vivo. EGFR is also able to directly phosphorylate the eps15 product in …

1999年8月1日 · Eps15 was originally identified as a substrate for the kinase activity of the epidermal growth factor receptor (EGFR). Eps15 has a tripartite structure comprising a NH2-terminal portion, which contains three EH domains, a central putative coiled-coil region, and a COOH-terminal domain containing multiple copies of the amino acid triplet ...

2016年2月19日 · ESP15 localizes to coated pits on cell membranes and shuttles between the nucleus and cytoplasm, suggesting that it has a role in clathrin-dependent endocytosis and in nucleocytoplasmic trafficking (Poupon et al., 2002).

Eps15 has been shown to bind to AP-1 and AP-2 complexes, to bind to inositol lipids and to several other proteins involved in the regulation of intracellular trafficking. In addition, Eps15 has been detected in the nucleus of mammalian cells. Activation of growth factor receptors induces tyrosine phosphorylation and mono-ubiquitination of Eps15.